Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 11/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 2/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6666961 | 0.95 | ALDH1A1 (0.39) | CTSKALDH1A1ATMKLK5 | |
| SCHEMBL6668504 | 0.95 | ALDH1A1 (0.39) | CTSKALDH1A1ATMKLK5 | |
| SCHEMBL6692480 | 0.93 | ADRB2 (0.38) | CTSKALDH1A1ATMKLK5 | |
| SCHEMBL6666632 | 0.93 | ALDH1A1 (0.40) | CTSKALDH1A1CCNE1CDK2CDK5 | |
| SCHEMBL6663482 | 0.91 | KLK5 (0.41) | CTSKALDH1A1ATMKLK5 | |
| SCHEMBL9378904 | 0.86 | CTSS (0.41) | CTSKATMKLK5 | |
| SCHEMBL9372986 | 0.86 | ATM (0.38) | CTSKALDH1A1ATMKLK5REN | |
| SCHEMBL9373933 | 0.86 | CTSK (0.39) | CTSKALDH1A1ATMKLK5 | |
| SCHEMBL9373974 | 0.85 | PTPRB (0.39) | CTSKALDH1A1ATMKLK5REN | |
| SCHEMBL9379291 | 0.85 | ATM (0.39) | CTSKALDH1A1ATMKLK5REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450795-A1 | PEPTIDE ISOSTERES CONTAINING A HETEROCYCLE USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003047576-A1 | PEPTIDE ISOSTERES CONTAINING A HETEROCYCLE USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2003-06-12 | — | — | WO | disclosed |