Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.41 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | MTTP | P55157 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6689430 | 0.89 | CTSS (0.37) | CTSSCTSLCTSKMEN1KMT2A | |
| SCHEMBL6688100 | 0.86 | CTSS (0.41) | CTSSCTSLCTSKALDH1A1MEN1 | |
| SCHEMBL6689803 | 0.81 | SIGMAR1 (0.39) | CTSSCTSLALDH1A1MEN1KMT2A | |
| SCHEMBL4799699 | 0.78 | CTSS (0.55) | CTSSCTSLS1PR3CTSK | |
| SCHEMBL6688064 | 0.72 | CTSS (0.42) | CTSSCTSLCTSKALDH1A1MEN1 | |
| SCHEMBL6693567 | 0.69 | CTSS (0.68) | CTSSCTSLCTSK | |
| SCHEMBL6691378 | 0.69 | CTSS (0.60) | CTSSCTSLCTSK | |
| SCHEMBL6693488 | 0.69 | CTSS (0.61) | CTSSCTSLCTSKGPR132 | |
| SCHEMBL6689978 | 0.69 | SIGMAR1 (0.33) | CTSSCTSLRAB9A | |
| SCHEMBL6691403 | 0.68 | CTSS (0.62) | CTSSCTSLCTSKGPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004084843-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |