Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 9/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 7/20 | 0.54 |
| ▸ | TUBB | P07437 | 7/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.54 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.54 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.54 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.54 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.54 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6692393 | 0.84 | THRB (0.39) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6693009 | 0.81 | KDM4E (0.49) | ALDH1A1MEN1LMNAHPGDKMT2A | |
| SCHEMBL6694690 | 0.81 | RORC (0.56) | THRBRORC | |
| SCHEMBL6692435 | 0.80 | SMN1; SMN2 (0.39) | ALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL6693303 | 0.80 | TUBB1 (0.46) | TUBB1ALDH1A1LMNA | |
| SCHEMBL6694977 | 0.80 | L3MBTL1 (0.42) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6691486 | 0.78 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2A | |
| SCHEMBL13518328 | 0.76 | TUBB1 (0.79) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6692377 | 0.71 | LMNA (0.58) | THRBALDH1A1MEN1LMNAHPGD | |
| SCHEMBL6697148 | 0.71 | MAPK1 (0.37) | THRBRORCALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6747048-B2 | TREATING DISEASES OR DISORDERS ASSOCIATED WITH METABOLISM DYSFUNCTION OR WHICH ARE DEPENDENT UPON THE EXPRESSION OF A T3 REGULATED GENE, | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-08 | — | — | US | disclosed |
| US-20040039028-A1 | Pyridine-based thyroid receptor ligands | BRISTOL-MYERS SQUIBB COMPANY | 2004-02-26 | — | — | US | disclosed |
| WO-2003094845-A2 | PYRIDINE-BASED THYROID RECEPTOR LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040039028-A1 | Pyridine-based thyroid receptor ligands | TSHR, THRB, THRA | TUBB1 3607/4885TUBB4A 3977/4885TUBB 3377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.