Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | FHIT | P49789 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA7 | P43166 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11635514 | 0.92 | ALDH1A1 (0.39) | ALDH1A1HPGDGAAMAPTSMN1; SMN2 | |
| SCHEMBL669565 | 0.90 | GAA (0.45) | ALDH1A1HPGDGAAMAPTSMN1; SMN2 | |
| SCHEMBL11632785 | 0.81 | GAA (0.43) | ALDH1A1HPGDGAAMAPTSMN1; SMN2 | |
| SCHEMBL11634990 | 0.78 | ALDH1A1 (0.39) | ALDH1A1HPGDGAAMAPTSMN1; SMN2 | |
| SCHEMBL1850132 | 0.74 | KDM4E (0.47) | ALDH1A1HPGDGAAMAPTSMN1; SMN2 | |
| SCHEMBL8440916 | 0.74 | MAPK1 (0.47) | ALDH1A1HPGDGAAMAPTSMN1; SMN2 | |
| SCHEMBL11634168 | 0.74 | MAPT (0.34) | ALDH1A1HPGDGAAMAPTSMN1; SMN2 | |
| SCHEMBL11632117 | 0.74 | MAPT (0.38) | ALDH1A1HPGDGAAMAPTSMN1; SMN2 | |
| SCHEMBL11633572 | 0.73 | NPSR1 (0.38) | ALDH1A1HPGDGAAMAPTSMN1; SMN2 | |
| SCHEMBL11636776 | 0.73 | TSHR (0.38) | ALDH1A1HPGDGAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142676-A1 | Oxathiazine and dithiine oxides as inhibitors of sulfhydryl-dependent biomolecules | CHEE GAIK-LEAN (CA) | 2012-06-07 | — | — | US | disclosed |
| WO-2012024083-A1 | OXATHIAZINE AND DITHIINE OXIDES AS INHIBITORS OF SULFHYDRYL-DEPENDENT BIOMOLECULES | CHEMTURA CORPORATION (US) | 2012-02-23 | — | — | WO | disclosed |
| US-4109006-A | 1,4-DITHIINOXIDES | WARREN-TEED LABORATORIES, INC. (US) | 1978-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142676-A1 | Oxathiazine and dithiine oxides as inhibitors of sulfhydryl-dependent biomolecules | HPGDS, SHMT1, QSOX1 | ALDH1A1 1163/4885HPGD 20/4885GAA 2499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.