Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3195611 | 0.78 | HDAC8 (0.49) | HDAC8HDAC6ALDH1A1KDM4ELMNA | |
| SCHEMBL6700771 | 0.78 | DHPS (0.48) | HDAC8HDAC6AGTR1AGTR2CYP11B1 | |
| SCHEMBL12514860 | 0.76 | ALDH1A1 (0.58) | ALDH1A1MAPK1KDM4EEGFRLMNA | |
| SCHEMBL6695778 | 0.73 | MAPK1 (0.50) | HDAC8HDAC6ALDH1A1MAPK1PPARG | |
| SCHEMBL3202371 | 0.73 | CYP11B1 (0.45) | ALDH1A1KDM4EMEN1KMT2ACYP11B1 | |
| SCHEMBL6691960 | 0.72 | HTR6 (0.59) | HDAC8HDAC6ALDH1A1MAPK1KMT2A | |
| SCHEMBL6226587 | 0.71 | CHRM1 (0.41) | HDAC8HDAC6 | |
| SCHEMBL6225743 | 0.71 | CA12 (0.56) | HDAC6ALDH1A1MAPK1KDM4EMEN1 | |
| SCHEMBL6696330 | 0.69 | HDAC8 (0.46) | HDAC8HDAC6PPARGHDAC3HDAC4 | |
| SCHEMBL1249731 | 0.69 | MAPK1 (0.58) | ALDH1A1MAPK1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040229874-A1 | 5HT7 Antagonists and inverse agonists | PFIZER INC. | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229874-A1 | 5HT7 Antagonists and inverse agonists | HTR7, HTR1A, HTR1B | HDAC8 2221/4885HDAC6 1841/4885ALDH1A1 1099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.