Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 9/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6701193 | 0.79 | MMP13 (0.64) | MMP13LMNASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6698933 | 0.78 | MMP13 (0.49) | MMP13LMNASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6813762 | 0.78 | MMP13 (0.41) | MMP13LMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6703411 | 0.77 | MMP13 (0.56) | MMP13LMNASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6813767 | 0.76 | MMP13 (0.39) | MMP13LMNASMN1; SMN2HPGD | |
| SCHEMBL6703316 | 0.75 | CNR2 (0.52) | MMP13LMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6704886 | 0.73 | MMP13 (0.56) | MMP13LMNASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6822798 | 0.73 | MMP13 (0.56) | MMP13LMNASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL6696806 | 0.72 | KDM4E (0.47) | MMP13LMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6297353 | 0.72 | MMP13 (1.00) | MMP13SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040038994-A1 | Pyrimidine fused bicyclic metalloproteinase inhibitors | WILSON MICHAEL WILLIAM (US) | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038994-A1 | Pyrimidine fused bicyclic metalloproteinase inhibitors | MMP9, MMP1, MMP2 | MMP13 13/4885LMNA 2847/4885SMN1; SMN2 3684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.