Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6696270 | 0.79 | MAPK1 (0.40) | MAPK1ALDH1A1PRMT5WDR77MITF | |
| SCHEMBL8499683 | 0.76 | L3MBTL1 (0.39) | MAPK1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL537566 | 0.73 | MAPK1 (1.00) | MAPK1EPHX2MAPT | |
| SCHEMBL6696196 | 0.71 | MAOA (0.40) | MAPK1ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL5796413 | 0.70 | SLC6A2 (0.47) | MAPK1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL10280392 | 0.68 | MAPK1 (0.47) | MAPK1ALDH1A1CYP1A2CYP2D6ALOX15 | |
| SCHEMBL2293652 | 0.68 | MEN1 (0.55) | ALDH1A1KDM4EHSD17B10LMNAHTT | |
| SCHEMBL15268712 | 0.67 | SLC6A2 (0.42) | CYP1A2CYP2D6SMN1; SMN2LMNAATM | |
| SCHEMBL8011431 | 0.67 | MAPT (0.45) | ALDH1A1LMNAHIF1AATMMAPT | |
| SCHEMBL4610464 | 0.67 | AAK1 (0.42) | KDM4ECYP1A2CYP2D6LMNAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040009972-A1 | Benzodiazepine inhibitors of mitochondial F1F0 ATP hydrolase and methods of inhibiting F1F0 ATP hydrolase | BRISTOL-MYERS COMPANY | 2004-01-15 | — | — | US | disclosed |
| WO-2003106628-A2 | BENZODIAZEPINE INHIBITORS OF MITOCHONDIAL F1F0 ATP HYDROLASE AND METHODS OF INHIBITING F1F0 ATP HYDROLASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009972-A1 | Benzodiazepine inhibitors of mitochondial F1F0 ATP hydrolase and methods of inhibiting F1F0 ATP hydrolase | MT-ATP6, MT-CO1, ATP5ME | MAPK1 4076/4885ALDH1A1 1084/4885KDM4E 2540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.