Sugi Predict

Sugi Predict / Compounds / SCHEMBL669840

SCHEMBL669840

SCHEMBL669840

CCc1cc(Cl)cc(CC)c1N

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTT P42858 2/20 0.50
▸ POLB P06746 1/20 0.50
▸ TP53 P04637 2/20 0.39
▸ CYP3A4 P08684 2/20 0.39
▸ TAAR1 Q96RJ0 1/20 0.38
▸ ALDH1A1 P00352 3/20 0.37
▸ MAPT P10636 1/20 0.37
▸ NOS3 P29474 1/20 0.35
▸ NOS1 P29475 1/20 0.35
▸ NOS2 P35228 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ GRIN2D O15399 1/20 0.34
▸ GRIN3B O60391 1/20 0.34
▸ GRIN1 Q05586 1/20 0.34
▸ GRIN2A Q12879 1/20 0.34
▸ GRIN2B Q13224 1/20 0.34
▸ GRIN2C Q14957 1/20 0.34
▸ GRIN3A Q8TCU5 1/20 0.34
▸ HPGD P15428 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL205507 0.88 HTT (0.41) HTTPOLBTP53CYP3A4TAAR1
SCHEMBL19743826 0.88 HTT (0.41) HTTPOLBTP53CYP3A4TAAR1
SCHEMBL11175266 0.86 HTT (0.49) HTTPOLBTP53CYP3A4TAAR1
SCHEMBL9976443 0.84 ALDH1A1 (0.38) HTTPOLBCYP3A4ALDH1A1MAPT
Hydrochloric Acid SCHEMBL11178447 0.84 ALDH1A1 (0.47) HTTPOLBTP53CYP3A4TAAR1
SCHEMBL946031 0.84 HTT (0.38) HTTPOLBTP53CYP3A4TAAR1
SCHEMBL11139099 0.84 HTT (0.38) HTTPOLBTP53CYP3A4TAAR1
SCHEMBL2919577 0.80 CA2 (0.48) HTTPOLBALDH1A1LMNACYP2C9
SCHEMBL21986386 0.80 ALDH1A1 (0.53) TP53CYP3A4ALDH1A1MAPTHPGD
SCHEMBL26761192 0.78 CYP3A4 (0.45) HTTPOLBTP53CYP3A4TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240400502-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME UNIV QUEENSLAND (AU) 2024-12-05 — — US disclosed
CN-113582889-B Sulfonylureas and related compounds and uses thereof 昆士兰大学 2024-09-20 — — CN disclosed
US-11845715-B2 — — 2023-12-19 — — US disclosed
US-11845715-B2 — — 2023-12-19 — — US disclosed
US-11845715-B2 — — 2023-12-19 — — US disclosed
US-11760735-B2 Compounds and compositions for treating conditions associated with NLRP activity NOVARTIS AG (CH) 2023-09-19 — — US disclosed
US-11760735-B2 Compounds and compositions for treating conditions associated with NLRP activity NOVARTIS AG (CH) 2023-09-19 — — US disclosed
US-11760735-B2 Compounds and compositions for treating conditions associated with NLRP activity NOVARTIS AG (CH) 2023-09-19 — — US disclosed
US-20230099258-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY IFM THERAPEUTICS, INC. 2023-03-30 — — US disclosed
US-11339136-B2 Compounds and compositions for treating conditions associated with NLRP activity NOVARTIS AG (CH) 2022-05-24 — — US disclosed
US-4418209-A ANTIULCER, ANTIARRYTHMIC, ANTIDIARRHEAL, ANTISPASMODIC, ANTIPARASITIC, AND ANTISECRETORY AGENTS WILLIAM H. RORER, INC. (US) 1983-11-29 — — US disclosed
US-4401833-A Process for the preparation of 4-chloro-2,6-dialkylanilines BAYER AKTIENGESELLSCHAFT (DE) 1983-08-30 — — US disclosed
EP-0052817-A1 Process for the preparation of 4-chloro-2,6 dialkyl anilines BAYER AG (DE) 1982-06-02 — — EP disclosed
US-4326075-A ANTIDIARRHEA AGENTS WILLIAM H. RORER, INC. (US) 1982-04-20 — — US disclosed
US-4203920-A ANTIDIARRHEAL WILLIAM H. RORER, INC. (US) 1980-05-20 — — US disclosed
US-4147804-A ANTIARRHYTHMIA AGENTS WILLIAM H. RORER, INC. (US) 1979-04-03 — — US disclosed
US-4060635-A Amidinoureas for treating diarrhea WILLIAM H. RORER, INC. (US) 1977-11-29 — — US disclosed
US-3948950-A HERBICIDES VELSICOL CHEMICAL CORPORATION (US) 1976-04-06 — — US disclosed
US-3942972-A Dioxolane substituted α-haloanilides as herbicides VELSICOL CHEMICAL CORPORATION (US) 1976-03-09 — — US disclosed
US-3940259-A Dioxane substituted-α-haloanilides as herbicides VELSICOL CHEMICAL CORPORATION (US) 1976-02-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11845715-B2 — NLRP3, PYCARD, NOD1 HTT 543/4885POLB 4781/4885TP53 1086/4885
US-20230099258-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY NLRP1, NLRP3, NOD1 HTT 2340/4885POLB 4213/4885TP53 2046/4885
US-11760735-B2 Compounds and compositions for treating conditions associated with NLRP activity NLRP1, NLRP3, NOD1 HTT 2340/4885POLB 4213/4885TP53 2046/4885
US-20240400502-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME NLRP3, PYCARD, IAPP HTT 934/4885POLB 4825/4885TP53 2564/4885
US-11339136-B2 Compounds and compositions for treating conditions associated with NLRP activity NLRP1, NLRP3, NOD1 HTT 2340/4885POLB 4213/4885TP53 2046/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.