Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 3/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NT5E | P21589 | 1/20 | 0.34 |
| ▸ | TYMS | P04818 | 2/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | EPM2A | O95278 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30224160 | 0.80 | PSMB1 (0.49) | PSMB1PSMB5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2950988 | 0.80 | PSMB1 (0.49) | PSMB1PSMB5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31104421 | 0.75 | KDM4E (0.41) | KDM4EALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15466928 | 0.75 | KDM4E (0.41) | KDM4EALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9919029 | 0.74 | PSMB1 (0.46) | PSMB1PSMB5MEN1KMT2ATYMS | |
| SCHEMBL31241139 | 0.73 | PSMB1 (0.55) | PSMB1PSMB5KDM4ETYMSLMNA | |
| SCHEMBL31559172 | 0.70 | PSMB1 (0.49) | PSMB1PSMB5MEN1KMT2AHTT | |
| SCHEMBL19332575 | 0.70 | PSMB1 (0.49) | PSMB1PSMB5MEN1KMT2AHTT | |
| SCHEMBL31559960 | 0.70 | PSMB1 (0.43) | PSMB1PSMB5MEN1KMT2ATYMS | |
| SCHEMBL31723349 | 0.69 | PSMB1 (0.48) | PSMB1PSMB5KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040044000-A1 | Isoquinoline derivatives as matrix metalloproteinase inhibitors | BUNKER AMY MAE (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044000-A1 | Isoquinoline derivatives as matrix metalloproteinase inhibitors | MMP1, MMP13, MMP9 | PSMB1 866/4885PSMB5 210/4885MEN1 3092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.