Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 13/20 | 0.61 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.55 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GGH | Q92820 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21538566 | 0.87 | FOLH1 (0.51) | FOLH1NAALAD2RIMKLASMN1; SMN2 | |
| SCHEMBL18190841 | 0.87 | FOLH1 (0.51) | FOLH1NAALAD2RIMKLASMN1; SMN2 | |
| SCHEMBL25267184 | 0.83 | SMN1; SMN2 (0.46) | FOLH1SMN1; SMN2 | |
| SCHEMBL31444322 | 0.83 | SMN1; SMN2 (0.46) | FOLH1SMN1; SMN2 | |
| SCHEMBL6763914 | 0.83 | SMN1; SMN2 (0.53) | FOLH1SMN1; SMN2 | |
| SCHEMBL6701850 | 0.82 | FOLH1 (0.44) | FOLH1SMN1; SMN2 | |
| SCHEMBL2234720 | 0.81 | MME (0.53) | FOLH1SMN1; SMN2 | |
| SCHEMBL2234718 | 0.81 | MME (0.53) | FOLH1SMN1; SMN2 | |
| SCHEMBL18190834 | 0.81 | ALDH1A1 (0.58) | FOLH1SMN1; SMN2 | |
| SCHEMBL14719917 | 0.81 | FOLH1 (0.60) | FOLH1NAALAD2RIMKLAGGH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387890-B1 | CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; SEXUAL DISORDERS | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2002-05-14 | — | — | US | claimed |
| EP-1049660-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2000-11-08 | — | — | EP | claimed |
| WO-1999019295-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1999-04-22 | — | — | WO | claimed |
| US-6723710-B2 | BORON GROUP-SUBSTITUTED ACYCLIC ALPHA AMINO ACIDS ARE USEFUL FOR INHIBITING A VARIETY OF ARINASE- AND NO SYNTHASE-RELATED DISORDERS, INCLUDING HEART DISEASE, GASTROINTESTINAL MOTILITY DISORDERS, AND PENILE ERECTILE DYSFUNCTION IN HUMANS. | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2004-04-20 | — | — | US | disclosed |
| US-20040063666-A1 | Compositions for inhibiting arginase activity | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2004-04-01 | — | — | US | disclosed |
| US-20030036529-A1 | Compositions and methods for inhibiting arginase activity | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2003-02-20 | — | — | US | disclosed |
| US-6387890-B1 | CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; SEXUAL DISORDERS | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2002-05-14 | — | — | US | disclosed |
| EP-1049660-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999019295-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1999-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063666-A1 | Compositions for inhibiting arginase activity | ARG1, PDE3A, ARG2 | FOLH1 296/4885NAALAD2 80/4885RIMKLA 357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.