Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL8573552 | 0.97 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL8530527 | 0.97 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL2898170 | 0.87 | MEN1 (0.48) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL2862081 | 0.84 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL7193959 | 0.79 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL28216031 | 0.79 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL3696191 | 0.79 | — | — | |
| Tromethamine SCHEMBL975 | 0.79 | — | — | |
| Tromethamine SCHEMBL17484 | 0.79 | MEN1 (1.00) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL670237 | 0.79 | MEN1 (0.59) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2475 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4656182-B1 | GLP-1 ANALOGUE COMPOSITIONS AND PREPARATION METHOD | GALENICUM HEALTH S L U (ES) | 2026-03-18 | — | — | EP | claimed |
| US-20260062351-A1 | HYDRAULIC CEMENT FOR CARBON DIOXIDE ENVIRONMENTS | HALLIBURTON ENERGY SERVICES INC (US) | 2026-03-05 | — | — | US | claimed |
| WO-2026049757-A1 | HYDRAULIC CEMENT FOR CARBON DIOXIDE ENVIRONMENTS | HALLIBURTON ENERGY SERVICES, INC. (US) | 2026-03-05 | — | — | WO | claimed |
| US-20250367264-A1 | GLP-1 ANALOGUE COMPOSITIONS AND PREPARATION METHOD | GALENICUM HEALTH S L U (ES) | 2025-12-04 | — | — | US | claimed |
| EP-4656182-A1 | GLP-1 ANALOGUE COMPOSITIONS AND PREPARATION METHOD | Galenicum Health S.L.U. (ES) | 2025-12-03 | — | — | EP | claimed |
| US-12453698-B2 | Pharmaceutical biodissolvable gels for drug delivery | AIVIVA BIOPHARMA, INC. (US) | 2025-10-28 | — | — | US | claimed |
| US-20250101303-A1 | ETCHING COMPOSITIONS | FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. | 2025-03-27 | — | — | US | claimed |
| US-11891599-B2 | Recovery of nucleic acids from solid supports | QIAGEN HEALTHCARE BIOTECHNOLOGIES SYSTEMS GMBH (DE) | 2024-02-06 | — | — | US | claimed |
| WO-2023124824-A1 | SALT OF GLP-1 AGONIST, CRYSTAL FORM THEREOF, AND USE THEREOF IN MEDICINES | 海思科医药集团股份有限公司 | 2023-07-06 | — | — | WO | claimed |
| CN-116390709-A | Permanent hair shaping composition | 威娜德国有限责任公司 | 2023-07-04 | — | — | CN | claimed |
| WO-1992006383-A1 | DILUENT AND METHOD FOR DETERMINATION OF TOTAL CALCIUM | BECKMAN INSTRUMENTS, INC. (US) | 1992-04-16 | — | — | WO | claimed |
| US-5041278-A | Encapsulation; solvent-free; administration in vivo; antiinflammatory agents; analgesics; anesthetics | THE LIPOSOME COMPANY, INC. (US) | 1991-08-20 | — | — | US | claimed |
| EP-0397119-A2 | Surface-modified polyacrylonitrile substrates | CYTEC TECHNOLOGY CORP. (US) | 1990-11-14 | — | — | EP | claimed |
| US-4826686-A | TRANSDERMAL PATCH FOR SUSTAINED RELEASE OF HYPOTENSIVE AGENT | BOEHRINGER INGELHEIM KG (DE) | 1989-05-02 | — | — | US | claimed |
| EP-0111836-A2 | Device and method for the quantitative determination of heparin in mammalian blood plasma and method for preparing the device | MILES INC. (US) | 1984-06-27 | — | — | EP | claimed |
| US-RE31517-E | ETHYLENEDIAMINETETRAACETIC ACID, RADIOIMMUNOASSAY, INCUBATION, ANGIOTENSIN | Fernandez de Castro, Aurora L. (US) | 1984-02-07 | — | — | US | claimed |
| EP-0092380-A2 | Antiallergic 4H-furo(3,2-b)indoles and their production | WARNER-LAMBERT COMPANY (US) | 1983-10-26 | — | — | EP | claimed |
| US-4253978-A | METAL SALTS OF HYDROCARBYL OXAZOLINE PHOSPHORODIHIOIC ACID | MOBIL OIL CORPORATION (US) | 1981-03-03 | — | — | US | claimed |
| US-4041147-A | Angiotensin iradioimmunoassay | E. R. SQUIBB & SONS, INC. (US) | 1977-08-09 | — | — | US | claimed |
| US-3984532-A | Method for quantitative determination of renin activity in blood employing phenyl methyl sulfonyl fluoride and polyethylene glycol | FERNANDEZ DE CASTRO AURORA L | 1976-10-05 | — | — | US | claimed |