Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.34 |
| ▸ | ITGAL | P20701 | 2/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6703120 | 1.00 | SLC6A5 (0.35) | SLC6A5PIN1ITGB2ICAM1ITGAL | |
| SCHEMBL27693415 | 0.87 | SLC6A5 (0.34) | SLC6A5PIN1ITGB2ICAM1ITGAL | |
| SCHEMBL4957716 | 0.87 | SLC6A5 (0.36) | SLC6A5PIN1HDAC6CPB2CPB1 | |
| SCHEMBL4182507 | 0.86 | PIN1 (0.47) | SLC6A5PIN1ITGB2ICAM1ITGAL | |
| SCHEMBL4182503 | 0.86 | PIN1 (0.47) | SLC6A5PIN1ITGB2ICAM1ITGAL | |
| SCHEMBL12780533 | 0.86 | PIN1 (0.40) | SLC6A5PIN1ITGB2ICAM1ITGAL | |
| SCHEMBL6308761 | 0.85 | PIN1 (0.34) | SLC6A5PIN1ITGB2ICAM1ITGAL | |
| SCHEMBL6308753 | 0.85 | PIN1 (0.34) | SLC6A5PIN1ITGB2ICAM1ITGAL | |
| SCHEMBL29893883 | 0.85 | PIN1 (0.34) | SLC6A5PIN1MMEPOLBP2RY14 | |
| SCHEMBL4295456 | 0.84 | ITGB3 (0.45) | SLC6A5PIN1CPB2CPB1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110713515-B | Metronidazole-sarcosyl-histidine dipeptide compound and preparation and application thereof | 南京益唯森生物科技有限公司 | 2023-03-24 | — | — | CN | claimed |
| CN-110713515-A | Metronidazole-sarcosyl-histidine dipeptide compound and preparation and application thereof | 南京益唯森生物科技有限公司 | 2020-01-21 | — | — | CN | claimed |
| CN-110713515-B | Metronidazole-sarcosyl-histidine dipeptide compound and preparation and application thereof | 南京益唯森生物科技有限公司 | 2023-03-24 | — | — | CN | disclosed |
| CN-110713515-B | Metronidazole-sarcosyl-histidine dipeptide compound and preparation and application thereof | 南京益唯森生物科技有限公司 | 2023-03-24 | — | — | CN | disclosed |
| CN-110713515-B | Metronidazole-sarcosyl-histidine dipeptide compound and preparation and application thereof | 南京益唯森生物科技有限公司 | 2023-03-24 | — | — | CN | disclosed |
| CN-110713515-A | Metronidazole-sarcosyl-histidine dipeptide compound and preparation and application thereof | 南京益唯森生物科技有限公司 | 2020-01-21 | — | — | CN | disclosed |
| US-20040220272-A1 | Propargyl glycine amino propargyl diol compounds for treatment of hypertension | G.D. SEARLE & CO. | 2004-11-04 | — | — | US | disclosed |
| US-20040192780-A1 | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension | G.D. SEARLE & CO. | 2004-09-30 | — | — | US | disclosed |
| US-6777572-B2 | PROPARGYL GLYCINE AMINO PROPARGYL DIOL DERIVATIVES ARE USEFUL AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION. | PHARMACIA CORPORATION (OF PFIZER INC.) | 2004-08-17 | — | — | US | disclosed |
| US-20040087801-A1 | Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension | G.D. SEARLE & CO. | 2004-05-06 | — | — | US | disclosed |
| US-20030236201-A1 | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension | G.D. SEARLE & CO. | 2003-12-25 | — | — | US | disclosed |
| US-5268391-A | Cardiovascular disorders | C. D. SEARLE & CO. (US) | 1993-12-07 | — | — | US | disclosed |
| US-5252591-A | Renin inhibitors | G. D. SEARLE & COMPANY | 1993-10-12 | — | — | US | disclosed |
| US-5246969-A | Oligopeptides as renin inhibitors | G. D. SEARLE & CO. (US) | 1993-09-21 | — | — | US | disclosed |
| US-5227401-A | ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G. D. SEARLE & CO. (US) | 1993-07-13 | — | — | US | disclosed |
| US-5223535-A | Renin inhibitors | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5212185-A | Enzyme inhibitors | G. D. SEARLE & CO. (US) | 1993-05-18 | — | — | US | disclosed |
| WO-1993009086-A1 | PROPARGYL GLYCINE AMINO PROPARGYL DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | disclosed |
| WO-1993009087-A1 | ETHYNYL ALANINE AMINO DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | disclosed |
| EP-0539976-A1 | Ethynyl-alanine-amino-diol compounds for treatment of hypertension | G.D. Searle & Co. (US) | 1993-05-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087801-A1 | Imidazolyl/benzimidazolyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension | REN, AGTR1, AGTR2 | SLC6A5 288/4885PIN1 1332/4885ITGB2 2420/4885 |
| US-20040220272-A1 | Propargyl glycine amino propargyl diol compounds for treatment of hypertension | REN, AGTR1, AGTR2 | SLC6A5 149/4885PIN1 2799/4885ITGB2 2464/4885 |
| US-20030236201-A1 | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension | REN, AGTR1, AGTR2 | SLC6A5 57/4885PIN1 4234/4885ITGB2 2700/4885 |
| US-20040192780-A1 | Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension | REN, AGTR1, AGTR2 | SLC6A5 57/4885PIN1 4234/4885ITGB2 2700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.