Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 3/20 | 0.41 |
| ▸ | VEGFA | P15692 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168393 | 0.90 | LMNA (0.46) | EPHX2NR1H4MAPK10ALDH1A1HDAC11 | |
| SCHEMBL5697085 | 0.88 | PSMB1 (0.46) | EPHX2NR1H4MAPK10ALDH1A1RHEB | |
| SCHEMBL5697046 | 0.88 | SIRT2 (0.39) | EPHX2NR1H4MAPK10RHEBVEGFA | |
| SCHEMBL8345034 | 0.87 | CRHBP (0.41) | EPHX2NR1H4MAPK10RHEBEGLN1 | |
| SCHEMBL6180026 | 0.82 | LMNA (0.40) | EPHX2NR1H4MAPK10ALDH1A1HDAC11 | |
| SCHEMBL6177868 | 0.82 | LMNA (0.50) | EPHX2ALDH1A1MMP13LMNASMN1; SMN2 | |
| SCHEMBL5697142 | 0.82 | MMP13 (0.58) | MAPK10MMP13CRHBPCRHR2RECQL | |
| SCHEMBL6179334 | 0.82 | MMP13 (0.48) | ALDH1A1EGLN1HDAC3HDAC1HDAC2 | |
| SCHEMBL6700025 | 0.81 | MMP13 (0.45) | EGLN1HDAC11HDAC8HDAC6HDAC3 | |
| SCHEMBL6248127 | 0.81 | MAPK10 (0.39) | MAPK10ALDH1A1RHEBVEGFAEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040044000-A1 | Isoquinoline derivatives as matrix metalloproteinase inhibitors | BUNKER AMY MAE (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044000-A1 | Isoquinoline derivatives as matrix metalloproteinase inhibitors | MMP1, MMP13, MMP9 | EPHX2 3042/4885NR1H4 1712/4885MAPK10 757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.