Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 2/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 2/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6708045 | 0.85 | ACE (0.46) | CTSSMMEACE | |
| SCHEMBL6706849 | 0.85 | ACE (0.46) | CTSSMMEACE | |
| SCHEMBL5230870 | 0.84 | PPARA (0.56) | PPARAPPARGFOLH1CTSSMME | |
| SCHEMBL7592364 | 0.83 | PPARA (0.50) | PPARAPPARGFOLH1CTSSMME | |
| SCHEMBL7588488 | 0.80 | FOLH1 (0.59) | PPARAPPARGFOLH1CTSSMME | |
| SCHEMBL27586123 | 0.80 | PPARA (0.66) | PPARAPPARGFOLH1CTSSMME | |
| SCHEMBL31163762 | 0.80 | PPARA (0.66) | PPARAPPARGFOLH1CTSSMME | |
| SCHEMBL9450975 | 0.78 | FOLH1 (0.54) | PPARAPPARGFOLH1CTSSMME | |
| SCHEMBL5347315 | 0.78 | FOLH1 (0.54) | PPARAPPARGFOLH1CTSSMME | |
| SCHEMBL4863387 | 0.78 | PPARA (0.63) | PPARAPPARGFOLH1CTSSMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831084-B1 | Agonism and antagonism; neuroprotection; strokes including thromboembolic and focal, global or tranient ischemic attack | WYETH | 2004-12-14 | — | — | US | disclosed |
| US-6828324-B2 | Provide neuroprotection and prevent, inhibit or limit processes of neurodegeneration in mammals | WYETH | 2004-12-07 | — | — | US | disclosed |
| US-20040162430-A1 | Branched adamantyl and noradamantyl aryl-and aralkylpiperazines with serotonin 5-HT 1A activity | WYETH (US) | 2004-08-19 | — | — | US | disclosed |
| EP-1276731-A2 | BRANCHED ADAMANTYL AND NORADAMANTYL ARYL- AND ARALKYLPIPERAZINES WITH SEROTONIN 5-HT 1A ACTIVITY | Wyeth (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001034586-A2 | BRANCHED ADAMANTYL AND NORADAMANTYL ARYL- AND ARALKYLPIPERAZINES WITH SEROTONIN 5-HT1A ACTIVITY | WYETH (US) | 2001-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162430-A1 | Branched adamantyl and noradamantyl aryl-and aralkylpiperazines with serotonin 5-HT 1A activity | HTR1A, HTR5A, PARL | PPARA 2813/4885PPARG 3082/4885FOLH1 4045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.