Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 2/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.44 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6706849 | 1.00 | ACE (0.46) | ACENPSR1ALDH1A1MAPTMME | |
| SCHEMBL6706558 | 0.85 | PPARA (0.55) | ACEMMECTSS | |
| Hydrochloric Acid SCHEMBL31684060 | 0.83 | NPSR1 (0.47) | ACENPSR1ALDH1A1MAPTMME | |
| SCHEMBL20272503 | 0.81 | NPSR1 (0.53) | ACENPSR1ALDH1A1MAPTMME | |
| SCHEMBL7191200 | 0.77 | ATM (0.47) | ALDH1A1KMT2AATMLMNA | |
| SCHEMBL7596254 | 0.76 | MME (0.57) | ACENPSR1MMEACE2L3MBTL1 | |
| SCHEMBL12207239 | 0.76 | MME (0.57) | ACENPSR1MMEACE2L3MBTL1 | |
| SCHEMBL29260783 | 0.76 | L3MBTL1 (0.51) | ACENPSR1ALDH1A1MAPTMME | |
| SCHEMBL6770155 | 0.75 | ACE (0.54) | ACENPSR1ALDH1A1MMEFPR2 | |
| SCHEMBL2476918 | 0.75 | ACE (0.54) | ACENPSR1ALDH1A1MAPTMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831084-B1 | Agonism and antagonism; neuroprotection; strokes including thromboembolic and focal, global or tranient ischemic attack | WYETH | 2004-12-14 | — | — | US | disclosed |
| US-6828324-B2 | Provide neuroprotection and prevent, inhibit or limit processes of neurodegeneration in mammals | WYETH | 2004-12-07 | — | — | US | disclosed |
| US-20040162430-A1 | Branched adamantyl and noradamantyl aryl-and aralkylpiperazines with serotonin 5-HT 1A activity | WYETH (US) | 2004-08-19 | — | — | US | disclosed |
| EP-1276731-A2 | BRANCHED ADAMANTYL AND NORADAMANTYL ARYL- AND ARALKYLPIPERAZINES WITH SEROTONIN 5-HT 1A ACTIVITY | Wyeth (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001034586-A2 | BRANCHED ADAMANTYL AND NORADAMANTYL ARYL- AND ARALKYLPIPERAZINES WITH SEROTONIN 5-HT1A ACTIVITY | WYETH (US) | 2001-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162430-A1 | Branched adamantyl and noradamantyl aryl-and aralkylpiperazines with serotonin 5-HT 1A activity | HTR1A, HTR5A, PARL | ACE 3059/4885NPSR1 236/4885ALDH1A1 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.