Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | TACR3 | P29371 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6253159 | 0.76 | BACE1 (0.35) | BACE1 | |
| SCHEMBL1315036 | 0.74 | IDO1 (0.46) | TSHRBACE1 | |
| SCHEMBL2093279 | 0.74 | CALM1 (0.50) | CALM1LTA4HIDH1 | |
| SCHEMBL7460513 | 0.73 | CALM1 (0.44) | CALM1LTA4HIDH1 | |
| SCHEMBL12300359 | 0.72 | IDO1 (0.35) | HPGDTSHRCALM1LTA4HBACE1 | |
| SCHEMBL27645219 | 0.70 | CALM1 (0.44) | CALM1LTA4HIDH1 | |
| SCHEMBL12300358 | 0.68 | LMNA (0.48) | HPGDIDH1BACE1TACR1 | |
| SCHEMBL6111479 | 0.68 | TSHR (0.48) | TSHR | |
| SCHEMBL4225544 | 0.68 | BACE1 (0.32) | BACE1 | |
| SCHEMBL8089580 | 0.66 | TP53 (0.46) | CALM1LTA4HIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040087552-A1 | Pyrrolidine modulators of ccr5 chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2004-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087552-A1 | Pyrrolidine modulators of ccr5 chemokine receptor activity | CCR5, CCR1, CXCR1 | HPGD 928/4885TSHR 859/4885CALM1 4318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.