Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | HTR2B | P41595 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15538073 | 0.79 | LMNA (0.31) | HIF1ALMNA | |
| SCHEMBL14803456 | 0.79 | ALDH1A1 (0.39) | TYRHPGDKDM4EUSP2HSD17B10 | |
| SCHEMBL16172617 | 0.77 | KDM4E (0.38) | TYRHPGDKDM4EUSP2HSD17B10 | |
| SCHEMBL14098461 | 0.77 | KDM4E (0.52) | TYRHPGDKDM4EUSP2HSD17B10 | |
| SCHEMBL31286010 | 0.77 | TYR (0.34) | TYRHPGDKDM4EUSP2HSD17B10 | |
| SCHEMBL20666765 | 0.76 | TYR (0.38) | TYRHPGDKDM4EUSP2HSD17B10 | |
| SCHEMBL13130224 | 0.76 | TYR (0.33) | TYRHPGDKDM4EUSP2HSD17B10 | |
| SCHEMBL12796015 | 0.74 | LMNA (0.31) | HPGDHIF1AGABRA1GABRB2LMNA | |
| SCHEMBL12848429 | 0.74 | NOS3 (0.34) | LMNATRPA1PTGS1CACNA1CCYP1A2 | |
| SCHEMBL20780323 | 0.73 | GLP1R (0.34) | HTR2CPDE2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422248-B2 | Phenyl- and pyridinyl-substituted 2,2,2-trifluoroethanols having anticonvulsant properties | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2015-06-11 | — | — | US | disclosed |
| US-20040248913-A1 | (Pyridinyl and pyrimidyl) trienoic acid derivatives as retinoid x receptor modulators | LIGAND PHARMACEUTICALS, INC. | 2004-12-09 | — | — | US | disclosed |
| EP-1414450-A1 | (PYRIDINYL AND PYRIMIDYL)TRIENOIC ACID DERIVATIVES AS RETINOID X RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003007950-A1 | (PYRIDINYL AND PYRIMIDYL) TRIENOIC ACID DERIVATIVES AS RETINOID X RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248913-A1 | (Pyridinyl and pyrimidyl) trienoic acid derivatives as retinoid x receptor modulators | TSHR, THRA, RXRA | TYR 1580/4885HPGD 1046/4885KDM4E 3687/4885 |
| US-20150158821-A1 | SUBSTITUTED PHENOLS HAVING ANTICONVULSANT PROPERTIES | PNMT, COMT, GABRE | TYR 261/4885HPGD 338/4885KDM4E 400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.