Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4337045 | 0.84 | KDM4E (0.43) | HSD17B10 | |
| SCHEMBL20604617 | 0.84 | HTR1A (0.38) | ADRA1ATAAR1IDO1HTR2A | |
| SCHEMBL6712170 | 0.84 | IDO1 (0.36) | ADRA1ATAAR1IDO1HSD17B10MTNR1A | |
| SCHEMBL17410218 | 0.82 | HTR2A (0.36) | ADRA1ATAAR1IDO1HTR2A | |
| SCHEMBL29991088 | 0.82 | HTR2A (0.36) | ADRA1ATAAR1IDO1HTR2A | |
| SCHEMBL4328070 | 0.81 | FDPS (0.48) | — | |
| SCHEMBL1247733 | 0.80 | TAAR1 (0.50) | TAAR1IDO1AOC3DHFRMTNR1A | |
| SCHEMBL3465581 | 0.80 | APLNR (0.45) | ADRA1ATAAR1IDO1HTR2A | |
| SCHEMBL1146357 | 0.77 | HTR2A (0.54) | TAAR1HTR2A | |
| SCHEMBL12888550 | 0.76 | KMT2A (0.44) | ADRA1ADHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2004-04-22 | — | — | US | disclosed |
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | PFIZER INC. | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077853-A1 | 2-amino-6-(2,4,5-substituted-phenyl)-pyridines | NOS3, NOS1, NOS2 | ADRA1A 352/4885TAAR1 572/4885IDO1 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.