Sugi Predict

Sugi Predict / Compounds / SCHEMBL6713792

SCHEMBL6713792

SCHEMBL6713792

COC(=O)C1=C(N(C)C(=O)CCCN2CCC(c3ccccc3)CC2)N=C(OC)NC1c1ccc2nonc2c1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ADRA1D P25100 6/20 0.42
▸ ADRA1A P35348 6/20 0.42
▸ ADRA1B P35368 6/20 0.42
▸ ADRA2A P08913 2/20 0.38
▸ ADRA2B P18089 2/20 0.38
▸ ADRA2C P18825 2/20 0.38
▸ DRD2 P14416 4/20 0.38
▸ DRD3 P35462 3/20 0.37
▸ HTR1A P08908 1/20 0.37
▸ HTR2A P28223 1/20 0.37
▸ SLC6A4 P31645 1/20 0.37
▸ HTR7 P34969 1/20 0.37
▸ OPRM1 P35372 2/20 0.36
▸ MAOB P27338 2/20 0.36
▸ MAOA P21397 1/20 0.36
▸ GAA P10253 1/20 0.36
▸ MCHR1 Q99705 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6711305 0.88 ADRA1A (0.55) ADRA1DADRA1AADRA1BDRD2MCHR1
SCHEMBL6713785 0.71 ADRA1D (0.51) ADRA1DADRA1AADRA1BADRA2AADRA2B
SCHEMBL6200462 0.71 GAA (0.39) ADRA1DADRA1AADRA1BGAA
SCHEMBL6770595 0.70 ADRA1D (0.54) ADRA1DADRA1AADRA1BADRA2AADRA2B
Hydrochloric Acid SCHEMBL6642002 0.69 ADRA1D (0.54) ADRA1DADRA1AADRA1BADRA2AADRA2B
SCHEMBL1614951 0.64 OPRM1 (0.50) ADRA1DADRA1AADRA1BADRA2AADRA2B
SCHEMBL7065101 0.63 ADRA1D (0.38) ADRA1DADRA1AADRA1BDRD2DRD3
SCHEMBL10595036 0.62 SLC18A3 (0.61) ADRA1DADRA1AADRA1BDRD2HTR1A
SCHEMBL28442705 0.61 SIGMAR1 (0.66) DRD2GAA
Hydrochloric Acid SCHEMBL10594777 0.61 DRD2 (0.66) DRD2HTR1AHTR2ASLC6A4HTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040242609-A1 Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof SYNAPTIC PHARMACEUTICAL CORPORATION 2004-12-02 — — US disclosed
US-6720324-B2 THERAPY FOR EATING DISORDERS, SEXUAL DISORDERS, PSYCHOLOGICAL DISORDERS SYNAPTIC PHARMACEUTICAL CORPORATION 2004-04-13 — — US disclosed
US-20040038855-A1 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof H. LUNDBECK A/S (DK) 2004-02-26 — — US disclosed
US-20030069261-A1 Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof H. LUNDBECK A/S (DK) 2003-04-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040038855-A1 DNA encoding a human melanin concentrating hormone receptor (MCH1) and uses thereof MCHR1, MCHR2, MC1R ADRA1D 100/4885ADRA1A 88/4885ADRA1B 143/4885
US-20040242609-A1 Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof MCHR1, MCHR2, MC4R ADRA1D 149/4885ADRA1A 161/4885ADRA1B 156/4885
US-20030069261-A1 Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof MCHR1, MCHR2, MC4R ADRA1D 149/4885ADRA1A 161/4885ADRA1B 156/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.