Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6919501 | 0.84 | MAPK1 (0.47) | MAPK1MAPTNPSR1L3MBTL1ALDH1A1 | |
| Bicarbonate SCHEMBL6919502 | 0.84 | MAPK1 (0.47) | MAPK1MAPTNPSR1L3MBTL1ALDH1A1 | |
| Bicarbonate SCHEMBL6919500 | 0.83 | MAPK1 (0.47) | MAPK1MAPTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL1531299 | 0.82 | TDP1 (0.57) | MAPK1MAPTNPSR1L3MBTL1ALDH1A1 | |
| Bicarbonate SCHEMBL6716536 | 0.81 | HTR2C (0.48) | MAPK1MAPTNPSR1L3MBTL1ALDH1A1 | |
| Bicarbonate SCHEMBL6716542 | 0.81 | HTR2C (0.48) | MAPK1MAPTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL7064744 | 0.80 | DRD2 (0.60) | MAPK1MAPTALDH1A1SMN1; SMN2KMT2A | |
| Bicarbonate SCHEMBL6716532 | 0.80 | CYP2D6 (0.47) | MAPK1MAPTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL6781971 | 0.80 | MAPK1 (0.52) | MAPK1MAPTNPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL6791221 | 0.80 | MAPK1 (0.47) | MAPK1MAPTNPSR1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313477-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-1313477-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002005819-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-24 | — | — | WO | disclosed |