Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylacetic Acid SCHEMBL28818261 | 0.82 | AKR1B1 (0.71) | CES2CES1AKR1B1CYP1A2GAA | |
| SCHEMBL4903950 | 0.75 | CTNNB1 (0.58) | CES2CES1AKR1B1SMN1; SMN2NPC1 | |
| SCHEMBL7088783 | 0.71 | ALDH1A1 (0.52) | SMN1; SMN2NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL19996729 | 0.70 | TDP1 (0.56) | SMN1; SMN2HPGDRAB9AMAPTL3MBTL1 | |
| SCHEMBL4175858 | 0.69 | KDM4E (0.56) | CES2CES1AKR1B1SMN1; SMN2NPC1 | |
| SCHEMBL4430783 | 0.69 | MAPT (0.67) | CES2CES1AKR1B1SMN1; SMN2NPC1 | |
| SCHEMBL363388 | 0.69 | GRM1 (0.57) | CES2CES1AKR1B1SMN1; SMN2NPC1 | |
| SCHEMBL7129800 | 0.69 | MAPT (0.80) | CES2CES1AKR1B1SMN1; SMN2NPC1 | |
| SCHEMBL24800 | 0.69 | MAPT (0.73) | CES2CES1AKR1B1SMN1; SMN2NPC1 | |
| SCHEMBL7129795 | 0.69 | MEN1 (0.62) | CES2CES1AKR1B1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11844802-B2 | Compounds and compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2023-12-19 | — | — | US | disclosed |
| US-20230044670-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | UNIV EMORY (US) | 2023-02-09 | — | — | US | disclosed |
| US-11471461-B2 | Compounds and compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2022-10-18 | — | — | US | disclosed |
| US-20210100806-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | UNIV EMORY (US) | 2021-04-08 | — | — | US | disclosed |
| US-10888565-B2 | Compounds and compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2021-01-12 | — | — | US | disclosed |
| US-20200121687-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | UNIV EMORY (US) | 2020-04-23 | — | — | US | disclosed |
| US-20180207166-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-07-26 | — | — | US | disclosed |
| US-9808464-B2 | Compounds and compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2017-11-07 | — | — | US | disclosed |
| EP-3187197-A1 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | Emory University (US) | 2017-07-05 | — | — | EP | disclosed |
| EP-2605804-B1 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | UNIV EMORY (US) | 2017-03-15 | — | — | EP | disclosed |
| US-20170035771-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-02-09 | — | — | US | disclosed |
| US-9511071-B2 | Compounds and compositions for ossification and methods related thereto | EMORY UNIVERSITY (US) | 2016-12-06 | — | — | US | disclosed |
| EP-2605804-A2 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | Emory University (US) | 2013-06-26 | — | — | EP | disclosed |
| US-20130137634-A1 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2013-05-30 | — | — | US | disclosed |
| US-8330039-B2 | Solar cell modules with poly(vinyl butyral) encapsulant comprising unsaturated heterocyclic compound | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-12-11 | — | — | US | disclosed |
| WO-2012024489-A2 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2012-02-23 | — | — | WO | disclosed |
| US-20100180947-A1 | SOLAR CELL MODULES WITH POLY(VINYL BUTYRAL) ENCAPSULANT COMPRISING UNSATURATED HETEROCYCLIC COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10888565-B2 | Compounds and compositions for ossification and methods related thereto | BMP2, SOST, BMP4 | CES2 4565/4885CES1 4633/4885AKR1B1 2607/4885 |
| US-20130137634-A1 | COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO | BMP2, SOST, BMP4 | CES2 4565/4885CES1 4633/4885AKR1B1 2607/4885 |
| US-20180207166-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | BMP2, SOST, BMP4 | CES2 4565/4885CES1 4633/4885AKR1B1 2607/4885 |
| US-11471461-B2 | Compounds and compositions for ossification and methods related thereto | BMP2, SOST, BMP4 | CES2 4565/4885CES1 4633/4885AKR1B1 2607/4885 |
| US-20230044670-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | BMP2, SOST, BMP4 | CES2 4565/4885CES1 4633/4885AKR1B1 2607/4885 |
| US-20210100806-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | BMP2, SOST, BMP4 | CES2 4565/4885CES1 4633/4885AKR1B1 2607/4885 |
| US-20170035771-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | BMP2, SOST, BMP4 | CES2 4565/4885CES1 4633/4885AKR1B1 2607/4885 |
| US-20200121687-A1 | Compounds and Compositions for Ossification and Methods Related Thereto | BMP2, SOST, BMP4 | CES2 4565/4885CES1 4633/4885AKR1B1 2607/4885 |
| US-11844802-B2 | Compounds and compositions for ossification and methods related thereto | BMP2, SOST, BMP4 | CES2 4565/4885CES1 4633/4885AKR1B1 2607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.