SCHEMBL6723685

SCHEMBL6723685

Cc1cnc(-n2ccc(C(F)(F)F)n2)nc1Oc1csc(C(F)(F)F)c1

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 1/20 0.37
IDH1 O75874 12/20 0.36
IDH2 P48735 1/20 0.36
GABRA1 P14867 1/20 0.32
GABRG2 P18507 1/20 0.32
GABRB3 P28472 1/20 0.32
MAPT P10636 2/20 0.31
NPC1 O15118 1/20 0.31
THRB P10828 1/20 0.30
BCL6 P41182 1/20 0.30
SCN9A Q15858 1/20 0.30
SLC6A2 P23975 1/20 0.30
SLC6A4 P31645 1/20 0.30
SLC6A3 Q01959 1/20 0.30
MCHR1 Q99705 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6181367 0.83 PRMT6 (0.38) PRMT6IDH1IDH2MAPTNPC1
SCHEMBL5547613 0.81 KDM4E (0.31)
SCHEMBL7873623 0.80 ALDH1A1 (0.44) MAPTSLC6A2SLC6A4SLC6A3
SCHEMBL6182022 0.77 PRMT6 (0.37) PRMT6IDH1IDH2MAPTNPC1
SCHEMBL7877675 0.76 GABRA1 (0.37) PRMT6IDH1IDH2GABRA1GABRG2
SCHEMBL6178955 0.75 PRMT6 (0.34) PRMT6IDH1IDH2SCN9A
SCHEMBL6176672 0.72 L3MBTL1 (0.37) PRMT6IDH1IDH2GABRA1GABRG2
SCHEMBL5215254 0.71 CYP1A2 (0.41) MAPTNPC1
SCHEMBL5211817 0.71 NPSR1 (0.38) MAPTNPC1
SCHEMBL6176976 0.71 PRMT6 (0.34) PRMT6IDH1IDH2SCN9AMCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040198758-A1 N-heterocyclyl substituted thienyloxy-pyrimidines used as herbicides BASF AKTIENGESELLSCHAFT (DE) 2004-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040198758-A1 N-heterocyclyl substituted thienyloxy-pyrimidines used as herbicides CBR3, CBR1, CBX8 PRMT6 2296/4885IDH1 214/4885IDH2 361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.