Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17884680 | 0.82 | ALDH1A1 (0.48) | ALDH1A1CCR5PYCR1MAPK1POLB | |
| SCHEMBL12483803 | 0.79 | KMT2A (0.42) | ALDH1A1KMT2AGAAPTGS2PTGS1 | |
| SCHEMBL1336385 | 0.77 | ALDH1A1 (0.37) | ALDH1A1CCR5PYCR1MAPK1KMT2A | |
| SCHEMBL21177435 | 0.77 | CCR5 (0.49) | ALDH1A1CCR5PYCR1MAPK1KMT2A | |
| SCHEMBL415375 | 0.77 | ALDH1A1 (0.38) | ALDH1A1CCR5PYCR1MAPK1POLB | |
| SCHEMBL14758469 | 0.77 | LMNA (0.40) | ALDH1A1CCR5PYCR1POLBKMT2A | |
| SCHEMBL9566865 | 0.76 | ALOX15 (0.42) | ALDH1A1CCR5PYCR1MAPK1POLB | |
| SCHEMBL2616324 | 0.76 | GAA (0.59) | PYCR1MAPK1POLBKMT2AGAA | |
| SCHEMBL14808309 | 0.74 | HRH4 (0.41) | ALDH1A1CCR5PYCR1MAPK1POLB | |
| SCHEMBL3789309 | 0.74 | ALDH1A1 (0.46) | ALDH1A1MAPK1KMT2AGAAPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040158074-A1 | Substituted biphenyl compounds for the treatment of inflammation | G.D. SEARLE & CO. | 2004-08-12 | — | — | US | disclosed |
| US-6677488-B2 | AS AN EXAMPLE, 4-(4,5-DIFLUORO-2-(3-CHLORO-4-FLUOROPHENYL) PHENYLBENZENESULFONAMIDE; ANTIARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; PROSTAGLANDIN INHIBITORS; SIDE EFFECT REDUCTION | G.D. SEARLE & CO. | 2004-01-13 | — | — | US | disclosed |
| US-20020169206-A1 | Substituted biphenyl compounds for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2002-11-14 | — | — | US | disclosed |
| EP-0794942-B1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-05-31 | — | — | EP | disclosed |
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |
| EP-0794942-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016934-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169206-A1 | Substituted biphenyl compounds for the treatment of inflammation | AHR, ARNT, GPBAR1 | ALDH1A1 241/4885CCR5 618/4885PYCR1 1077/4885 |
| US-20040158074-A1 | Substituted biphenyl compounds for the treatment of inflammation | AHR, ARNT, GPBAR1 | ALDH1A1 241/4885CCR5 618/4885PYCR1 1077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.