Sugi Predict

Sugi Predict / Compounds / SCHEMBL6735745

SCHEMBL6735745

SCHEMBL6735745

Cc1ccc(-c2[nH]c(C(F)F)nc2-c2cc(F)c(S(C)(=O)=O)cc2F)cc1C

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ PTGS2 P35354 9/20 0.42
▸ PTGS1 P23219 2/20 0.36
▸ ALOX5 P09917 1/20 0.34
▸ TYK2 P29597 6/20 0.34
▸ KDM4E B2RXH2 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ ALOX5AP P20292 2/20 0.32
▸ FEN1 P39748 2/20 0.32
▸ KIT P10721 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6729810 0.94 PTGS2 (0.42) PTGS2PTGS1ALOX5TYK2KDM4E
SCHEMBL6740179 0.94 PTGS2 (0.34) PTGS2PTGS1ALOX5TYK2KDM4E
SCHEMBL6737558 0.91 PTGS2 (0.33) PTGS2PTGS1ALOX5TYK2KDM4E
SCHEMBL6738743 0.91 PTGS2 (0.33) PTGS2PTGS1ALOX5TYK2KDM4E
SCHEMBL6734473 0.91 PTGS2 (0.45) PTGS2PTGS1ALOX5TYK2
SCHEMBL6739821 0.91 PTGS2 (0.45) PTGS2PTGS1ALOX5TYK2
SCHEMBL6732359 0.89 ALOX5 (0.35) PTGS2PTGS1ALOX5KDM4EALDH1A1
SCHEMBL6734417 0.89 ALDH1A1 (0.41) PTGS2PTGS1ALOX5TYK2KDM4E
SCHEMBL6739124 0.89 NR1H2 (0.38) PTGS2ALOX5TYK2ALOX5APFEN1
SCHEMBL6739955 0.89 NR1H2 (0.38) PTGS2PTGS1ALOX5TYK2ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6699884-B2 ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. PHARMACIA CORPORATION 2004-03-02 — — US claimed
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2004-07-15 — — US disclosed
US-6699884-B2 ANTIINFLAMMATORY CYCLOOXYGENASE INHIBITORS. PHARMACIA CORPORATION 2004-03-02 — — US disclosed
US-6673818-B2 TREATING CYCLOOXYGENASE-2 MEDIATED DISORDERS, SUCH AS ARTHRITIS, PAIN, FEVER AND CANCER PHARMACIA CORPORATION 2004-01-06 — — US disclosed
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-08-07 — — US disclosed
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation PHARMACIA CORPORATION 2003-02-13 — — US disclosed
EP-1251126-A2 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation Pharmacia Corporation (US) 2002-10-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040138261-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 PTGS2 10/4885PTGS1 4/4885ALOX5 165/4885
US-20030149078-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 PTGS2 10/4885PTGS1 4/4885ALOX5 165/4885
US-20030032657-A1 Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation FPR1, FPR2, FPR3 PTGS2 10/4885PTGS1 4/4885ALOX5 165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.