Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | DRD3 | P35462 | 5/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6741203 | 0.85 | KCNJ1 (0.47) | KCNJ1KCNH2DRD2DRD3CHRNA7 | |
| SCHEMBL6741839 | 0.84 | MEN1 (0.38) | KDM1ATRPA1 | |
| SCHEMBL7948923 | 0.83 | KCNH2 (0.52) | KCNJ1KCNH2DRD2DRD3DPP4 | |
| SCHEMBL6999087 | 0.82 | KCNH2 (0.67) | KCNJ1KCNH2DRD2DRD3 | |
| SCHEMBL6736841 | 0.80 | HTR1A (0.41) | KCNJ1KCNH2DRD2DRD3CHRNA7 | |
| SCHEMBL6737941 | 0.79 | KCNH2 (0.52) | KCNH2ALDH1A1L3MBTL1 | |
| SCHEMBL6737171 | 0.79 | KCNH2 (0.52) | KCNH2ALDH1A1L3MBTL1 | |
| SCHEMBL6743201 | 0.78 | NAMPT (0.44) | KCNJ1KCNH2DRD2DRD3CHRNA7 | |
| SCHEMBL6743285 | 0.78 | KCNH2 (0.43) | KCNH2CHRNA7KDM1AALDH1A1 | |
| SCHEMBL6733588 | 0.77 | SLC1A2 (0.44) | KCNH2CHRNA7KDM1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040229900-A1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ASTRAZENECA AB (SE) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229900-A1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ADRA1B, ADRB2, ADRA1D | KCNJ1 167/4885KCNH2 13/4885DRD2 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.