Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | GAA | P10253 | 4/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | USP2 | O75604 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6741895 | 1.00 | ALDH1A1 (0.71) | ALDH1A1GAAMAPTL3MBTL1MEN1 | |
| SCHEMBL6744695 | 0.82 | MAPT (0.49) | ALDH1A1GAAMAPTL3MBTL1MEN1 | |
| SCHEMBL22017070 | 0.82 | NPC1 (0.52) | ALDH1A1GAAMAPTL3MBTL1MEN1 | |
| SCHEMBL6744700 | 0.82 | MAPT (0.49) | ALDH1A1GAAMAPTL3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL6744785 | 0.81 | MAPT (0.48) | ALDH1A1GAAMAPTL3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL6744777 | 0.81 | MAPT (0.48) | ALDH1A1GAAMAPTL3MBTL1MEN1 | |
| SCHEMBL22017069 | 0.80 | LMNA (0.61) | ALDH1A1GAAMAPTL3MBTL1MEN1 | |
| SCHEMBL31105648 | 0.78 | HTT (0.46) | ALDH1A1GAAMAPTL3MBTL1MEN1 | |
| SCHEMBL17395927 | 0.78 | HTT (0.46) | ALDH1A1GAAMAPTL3MBTL1MEN1 | |
| SCHEMBL17395926 | 0.78 | HTT (0.46) | ALDH1A1GAAMAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030186993-A1 | Anti-malarial compounds, compositions and methods | KENNETH S. WARREN INSTITUTE | 2003-10-02 | — | — | US | claimed |
| US-6689777-B2 | DEPOLYMERIZING HEMOZOIN USING 2-IMINO-NAPHTHO(1,2-D)THIAZOL-5-OL DERIVATIVES | KENNETH S. WARREN INSTITUTE | 2004-02-10 | — | — | US | disclosed |
| US-20030186993-A1 | Anti-malarial compounds, compositions and methods | KENNETH S. WARREN INSTITUTE | 2003-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186993-A1 | Anti-malarial compounds, compositions and methods | TYR, CRYZ, RHOT2 | ALDH1A1 3325/4885GAA 260/4885MAPT 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.