SCHEMBL6744726

SCHEMBL6744726

CO[Si](OC)(OC)c1ccc(N(c2ccc(-c3ccc(N(c4cccc(C)c4)c4cccc(C)c4)cc3)cc2)c2cccc(C)c2)cc1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSD17B1 P14061 4/20 0.38
HSD17B2 P37059 4/20 0.38
EGFR P00533 2/20 0.33
CSF1R P07333 2/20 0.33
ACHE P22303 2/20 0.33
HTT P42858 3/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
TSHR P16473 1/20 0.33
LTB4R2 Q9NPC1 1/20 0.32
POLQ O75417 1/20 0.32
ENPP3 O14638 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6748597 0.95 ACHE (0.36) HSD17B1HSD17B2EGFRCSF1RACHE
SCHEMBL6748999 0.87 HSD17B1 (0.37) HSD17B1HSD17B2EGFRCSF1RACHE
SCHEMBL6851656 0.87 HSD17B1 (0.37) HSD17B1HSD17B2EGFRCSF1RACHE
SCHEMBL6751457 0.86
SCHEMBL6749493 0.86 ADRA2A (0.33) HSD17B1HSD17B2TSHR
SCHEMBL6748985 0.85 POLQ (0.38) HSD17B1HSD17B2HTTMEN1KMT2A
SCHEMBL6749520 0.85 ADRA2A (0.32) LMNA
SCHEMBL6748752 0.84 APP (0.36) MEN1KMT2A
SCHEMBL6748541 0.84 APP (0.36) MEN1KMT2A
SCHEMBL6750003 0.84 APP (0.36) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6696588-B2 OXIDATION POTENTIAL OF .3-1.5 V ON THE BASIS OF A STANDARD HYDROGEN ELECTRODE, ALKOXY AND AROMATIC AMINE DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-02-24 US disclosed
EP-0861845-B1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL CO (JP) 2003-05-28 EP disclosed
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED 2002-08-22 US disclosed
US-6369258-B1 SILICON COMPOUND WITH OXIDATION POTENTIAL ON HYDROGEN ELECTRODE POTENTIAL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-04-09 US disclosed
EP-0861845-A2 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-09-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same EPCAM, PIEZO1, OR10J3 HSD17B1 2188/4885HSD17B2 1969/4885EGFR 1149/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.