Sugi Predict

Sugi Predict / Compounds / SCHEMBL6851656

SCHEMBL6851656

SCHEMBL6851656

CO[Si](C)(OC)c1ccc(N(c2ccc(-c3ccc(N(c4cccc(C)c4)c4cccc(C)c4)cc3)cc2)c2cccc(C)c2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD17B1 P14061 3/20 0.37
▸ HSD17B2 P37059 3/20 0.37
▸ ENPP3 O14638 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ EGFR P00533 2/20 0.33
▸ CSF1R P07333 2/20 0.33
▸ ACHE P22303 2/20 0.33
▸ TSHR P16473 2/20 0.32
▸ MEN1 O00255 2/20 0.32
▸ HTT P42858 2/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ NPC1 O15118 1/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ HSD17B10 Q99714 1/20 0.32
▸ LTB4R2 Q9NPC1 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ TP53 P04637 1/20 0.31
▸ POLQ O75417 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6858715 0.95 ACHE (0.35) HSD17B1HSD17B2LMNAEGFRCSF1R
SCHEMBL6748999 0.88 HSD17B1 (0.37) HSD17B1HSD17B2ENPP3LMNAEGFR
SCHEMBL6744726 0.87 HSD17B1 (0.38) HSD17B1HSD17B2ENPP3LMNAEGFR
SCHEMBL6848032 0.86 ADRA2A (0.35) TSHR
SCHEMBL6848404 0.86 HTT (0.31) HTT
SCHEMBL6858713 0.86 HTT (0.36) HSD17B1HSD17B2ENPP3LMNATSHR
SCHEMBL6851639 0.85 ADRA2A (0.33) MEN1KMT2AKDM4ENPC1RAB9A
SCHEMBL15964799 0.85 NPC1 (0.33) HSD17B1HSD17B2MEN1KMT2AKDM4E
SCHEMBL6844565 0.85 NPC1 (0.38) MEN1KMT2AKDM4ENPC1RAB9A
SCHEMBL6850469 0.85 NPC1 (0.38) MEN1KMT2AKDM4ENPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6696588-B2 OXIDATION POTENTIAL OF .3-1.5 V ON THE BASIS OF A STANDARD HYDROGEN ELECTRODE, ALKOXY AND AROMATIC AMINE DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-02-24 — — US disclosed
EP-0861845-B1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL CO (JP) 2003-05-28 — — EP disclosed
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED 2002-08-22 — — US disclosed
US-6369258-B1 SILICON COMPOUND WITH OXIDATION POTENTIAL ON HYDROGEN ELECTRODE POTENTIAL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-04-09 — — US disclosed
EP-0861845-A2 Silicon-containing compound and organic electroluminescence device using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-09-02 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020115877-A1 Silicon-containing compound and organic electroluminescence device using the same EPCAM, PIEZO1, OR10J3 HSD17B1 2188/4885HSD17B2 1969/4885ENPP3 2689/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.