SCHEMBL6746737

SCHEMBL6746737

C[Si](C)(C)NC(=O)c1cc2ccccc2cc1C(=O)N[Si](C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.46
KMT2A Q03164 6/20 0.46
MAPT P10636 3/20 0.46
MITF O75030 1/20 0.46
GAA P10253 1/20 0.46
NCOA1 Q15788 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
NCOA3 Q9Y6Q9 1/20 0.46
NPC1 O15118 6/20 0.42
RAB9A P51151 5/20 0.42
POLB P06746 2/20 0.42
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 2/20 0.42
HPGD P15428 1/20 0.42
IDO1 P14902 1/20 0.41
CASP1 P29466 1/20 0.41
CASP7 P55210 1/20 0.41
MAOB P27338 3/20 0.41
MAOA P21397 2/20 0.41
GFER P55789 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6751578 0.83 POLB (0.45) MEN1KMT2AGAATDP1NPC1
SCHEMBL6680009 0.78 KMT2A (0.49) MEN1KMT2AGAAPOLBALDH1A1
SCHEMBL6744693 0.77 SORT1 (0.40) MEN1KMT2AMAPTGAANPC1
SCHEMBL12691557 0.76 KDM4E (0.59) MEN1KMT2AMAPTGAANPC1
SCHEMBL11226943 0.74 ALDH1A1 (0.45) MAPTGAAPOLBKDM4EALDH1A1
SCHEMBL8078737 0.74 POLB (0.38) MEN1KMT2AMAPTGAATDP1
SCHEMBL7938016 0.72 HDAC3 (0.54) MEN1KMT2AMAPTGAANPC1
SCHEMBL29023878 0.72 MAPT (0.78) MEN1KMT2AMAPTMITFGAA
SCHEMBL15984763 0.71 PLK1 (0.55) MEN1KMT2AMAPTMITFGAA
SCHEMBL12691550 0.71 CTSD (0.45) MEN1KMT2AMAPTGAANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1092729-B1 POLYMERIZATION CATALYST, NOVEL TRANSITION METAL COMPOUND, AND POLYMERIZATION METHOD AND COPOLYMER USING THEM MITSUI CHEMICALS INC (JP) 2012-09-26 EP disclosed
US-6703459-B1 ORGANIC TRANSITION METAL COMPLEXES HAVING SPECIFIC STRUCTURE, WHICH CAN FORM COPOLYMERS HAVING LINKAGE FORMED BY MIGRATION OF ACTIVE HYDROGEN OF UNSATURATED MONOMER MITSUI CHEMICALS, INC. (JP) 2004-03-09 US disclosed
EP-1092729-A1 POLYMERIZATION CATALYST, NOVEL TRANSITION METAL COMPOUND, AND POLYMERIZATION METHOD AND COPOLYMER USING THEM Mitsui Chemicals, Inc. (JP) 2001-04-18 EP disclosed