Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 6/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NT5E | P21589 | 1/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.42 |
| ▸ | PNP | P00491 | 1/20 | 0.42 |
| ▸ | KRAS | P01116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14896399 | 0.82 | HINT1 (0.49) | HINT1TAAR1HPGDNT5ETGM2 | |
| SCHEMBL16561344 | 0.81 | HINT1 (0.49) | HINT1HPGDNT5ETGM2TAS1R3 | |
| SCHEMBL6037194 | 0.80 | HINT1 (0.56) | HINT1HPGDNT5ETGM2GSK3A | |
| SCHEMBL16359926 | 0.78 | HINT1 (0.61) | HINT1HPGDNT5ETGM2TAS1R3 | |
| SCHEMBL1374872 | 0.78 | HINT1 (0.61) | HINT1HPGDNT5ETGM2TAS1R3 | |
| SCHEMBL23425431 | 0.78 | HINT1 (0.61) | HINT1HPGDNT5ETGM2TAS1R3 | |
| SCHEMBL20444711 | 0.78 | HINT1 (0.61) | HINT1HPGDNT5ETGM2TAS1R3 | |
| SCHEMBL22883381 | 0.78 | HINT1 (0.61) | HINT1HPGDNT5ETGM2TAS1R3 | |
| SCHEMBL23679991 | 0.78 | HINT1 (0.61) | HINT1HPGDNT5ETGM2TAS1R3 | |
| SCHEMBL1639395 | 0.78 | HINT1 (0.61) | HINT1HPGDNT5ETGM2TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040102618-A1 | Human RNase H1 and oligonucleotide compositions thereof | ISIS PHARMACEUTICALS, INC. | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102618-A1 | Human RNase H1 and oligonucleotide compositions thereof | RNASEH1, RNASE1, RNASEL | HINT1 281/4885TAAR1 4240/4885HPGD 3765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.