Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139625 | 1.00 | POLB (0.50) | POLBMAPK1ADRB2ADRB1ADRB3 | |
| SCHEMBL15081351 | 0.84 | KMT2A (0.50) | POLBMAPK1ADRB2ADRB1ADRB3 | |
| SCHEMBL4809726 | 0.83 | ALDH1A1 (0.60) | POLBMAPK1ADRB2ADRB1ADRB3 | |
| SCHEMBL9420685 | 0.82 | ADRB2 (0.56) | POLBMAPK1ADRB2ADRB1ADRB3 | |
| SCHEMBL14928501 | 0.82 | L3MBTL1 (0.52) | POLBMAPK1ADRB2ADRB1ADRB3 | |
| SCHEMBL14928880 | 0.82 | L3MBTL1 (0.52) | POLBMAPK1ADRB2ADRB1ADRB3 | |
| SCHEMBL28754539 | 0.81 | ALDH1A1 (0.53) | POLBMAPK1ADRB2ADRB1ADRB3 | |
| SCHEMBL16169034 | 0.81 | MAPK1 (0.53) | POLBMAPK1ADRB2ADRB1ADRB3 | |
| SCHEMBL14923550 | 0.80 | ADRB2 (0.48) | POLBMAPK1ADRB2ADRB1ADRB3 | |
| SCHEMBL696757 | 0.79 | L3MBTL1 (0.55) | POLBMAPK1ADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6703506-B2 | DIOXOLANE DERIVATIVES AND INTERMEDIATES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-03-09 | — | — | US | disclosed |
| US-20030158210-A1 | Amino acid ester containing azole antifungals | MEERPOEL LIEVEN (BE) | 2003-08-21 | — | — | US | disclosed |
| US-6512116-B2 | No drug resistance; intravenous | JANSSEN PHARMACEUTICA NV (BE) | 2003-01-28 | — | — | US | disclosed |
| US-20010039281-A1 | Amino acid ester containing azole antifungals | MEERPOEL LIEVEN (BE) | 2001-11-08 | — | — | US | disclosed |
| US-6262052-B1 | Amino acid ester containing azole antifungals | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-07-17 | — | — | US | disclosed |
| EP-0958289-A1 | AMINO ACID ESTER CONTAINING AZOLE ANTIFUNGALS | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998034934-A1 | AMINO ACID ESTER CONTAINING AZOLE ANTIFUNGALS | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158210-A1 | Amino acid ester containing azole antifungals | DAO, SLC7A1, IL4I1 | POLB 3755/4885MAPK1 1083/4885ADRB2 2139/4885 |
| US-20010039281-A1 | Amino acid ester containing azole antifungals | DAO, SLC7A1, IL4I1 | POLB 3755/4885MAPK1 1083/4885ADRB2 2139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.