Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618476 | 0.79 | SFRP1 (0.61) | ALDH1A1MAPTHPGDL3MBTL1 | |
| SCHEMBL15869133 | 0.77 | ALDH1A1 (0.64) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4541169 | 0.77 | ALDH1A1 (0.73) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL13297961 | 0.77 | L3MBTL1 (0.83) | ALDH1A1MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL17961793 | 0.76 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL8575945 | 0.75 | MAPT (0.63) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL28224297 | 0.75 | ALDH1A1 (0.69) | ALDH1A1MAPTMEN1KMT2AL3MBTL1 | |
| Tolpyrramide SCHEMBL667821 | 0.75 | KMT2A (0.64) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL24324266 | 0.75 | HSD17B10 (0.55) | ALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL5567042 | 0.75 | ALDH1A1 (0.75) | ALDH1A1HPGDMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4545530-A1 | TRICYCLIC GYRASE INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-04-30 | — | — | EP | disclosed |
| EP-3044225-B1 | TRICYCLIC GYRASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-12-18 | — | — | EP | disclosed |
| US-10385055-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-08-20 | — | — | US | disclosed |
| US-10385055-B2 | Tricyclic gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-08-20 | — | — | US | disclosed |
| US-20160222015-A1 | TRICYCLIC GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160222015-A1 | TRICYCLIC GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160222015-A1 | TRICYCLIC GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-08-04 | — | — | US | disclosed |
| US-20040092737-A1 | Benzopiperidine derivatives | EISAI CO., LTD. | 2004-05-13 | — | — | US | disclosed |
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |
| EP-0934941-A1 | BENZOPIPERIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 1999-08-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385055-B2 | Tricyclic gyrase inhibitors | TOP1, TOP2A, TOP2B | ALDH1A1 1898/4885MAPT 2765/4885HPGD 223/4885 |
| US-20040092737-A1 | Benzopiperidine derivatives | HLA-DRB1, HRH1, HRH2 | ALDH1A1 145/4885MAPT 1257/4885HPGD 592/4885 |
| US-20160222015-A1 | TRICYCLIC GYRASE INHIBITORS | TOP1, TOP2A, TOP2B | ALDH1A1 1898/4885MAPT 2765/4885HPGD 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.