SCHEMBL675528

SCHEMBL675528

Fc1cccc(C2(c3ccc(N4CCOCC4)cc3)C=Cc3c(cc(N4CCOCC4)c4ccccc34)O2)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.36
NPSR1 Q6W5P4 3/20 0.36
KDM4E B2RXH2 3/20 0.36
LMNA P02545 1/20 0.36
CYP3A4 P08684 1/20 0.36
THRB P10828 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
BLM P54132 1/20 0.36
OPRM1 P35372 1/20 0.35
OPRL1 P41146 1/20 0.35
ALDH1A1 P00352 5/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
POLB P06746 2/20 0.35
HPGD P15428 2/20 0.35
GAA P10253 2/20 0.35
TSHR P16473 1/20 0.35
HSD17B10 Q99714 1/20 0.35
NPC1 O15118 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12206758 0.96 ALDH1A1 (0.37) MAPTNPSR1KDM4ELMNACYP3A4
SCHEMBL12205327 0.96 ALDH1A1 (0.37) MAPTNPSR1KDM4ELMNACYP3A4
SCHEMBL21338487 0.96 ALDH1A1 (0.37) MAPTNPSR1KDM4ELMNACYP3A4
SCHEMBL12330830 0.93 NCF1 (0.36) MAPTNPSR1KDM4ELMNACYP3A4
SCHEMBL14092910 0.92 SMN1; SMN2 (0.33) MAPTNPSR1KDM4ELMNAALDH1A1
SCHEMBL29375632 0.91 KDM4E (0.40) MAPTNPSR1KDM4ELMNACYP3A4
SCHEMBL1408640 0.91 KDM4E (0.40) MAPTNPSR1KDM4ELMNACYP3A4
SCHEMBL6761051 0.89 ALDH1A1 (0.38) MAPTNPSR1KDM4ELMNACYP3A4
SCHEMBL6169045 0.89 ALDH1A1 (0.38) MAPTNPSR1KDM4ELMNACYP3A4
SCHEMBL2599669 0.88 KDM4E (0.39) MAPTNPSR1KDM4ELMNACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3480651-B1 SPECTACLE LENS AND SPECTACLES HOYA LENS THAILAND LTD (TH) 2023-09-13 EP disclosed
US-11709337-B2 Optical article HOYA LENS THAILAND LTD. (TH) 2023-07-25 US disclosed
US-11709337-B2 Optical article HOYA LENS THAILAND LTD. (TH) 2023-07-25 US disclosed
US-11526031-B2 Optical article HOYA LENS THAILAND LTD. (TH) 2022-12-13 US disclosed
US-10913226-B2 Method for manufacturing spectacle lens HOYA LENS THAILAND LTD. (TH) 2021-02-09 US disclosed
EP-1731947-B1 PHOTOCHROMIC OPTICAL ARTICLE TOKUYAMA CORP (JP) 2020-12-23 EP disclosed
US-20200142220-A1 OPTICAL ARTICLE HOYA LENS THAILAND LTD. (TH) 2020-05-07 US disclosed
US-20200142221-A1 OPTICAL ARTICLE HOYA LENS THAILAND LTD. (TH) 2020-05-07 US disclosed
EP-2040100-B1 METHOD FOR PRODUCING PHOTOCHROMIC OPTICAL ARTICLE TOKUYAMA CORP (JP) 2019-09-11 EP disclosed
US-10301415-B2 Polymerizable composition for optical member, optical member, and spectacle lens base HOYA LENS THAILAND LTD. (TH) 2019-05-28 US disclosed
US-20070065633-A1 Process for producing photochromic layered product TOKUYAMA CORPORATION (JP) 2007-03-22 US disclosed
US-7169941-B2 Photochromic composition TOKUYAMA CORPORATION (JP) 2007-01-30 US disclosed
US-7169941-B2 Photochromic composition TOKUYAMA CORPORATION (JP) 2007-01-30 US disclosed
EP-1559713-A1 Chromene compound Tokuyama Corporation (JP) 2005-08-03 EP disclosed
EP-1122251-B1 CHROMENE COMPOUNDS TOKUYAMA CORP (JP) 2005-07-20 EP disclosed
US-6719926-B2 Chromene compound TOKUYAMA CORPORATION (JP) 2004-04-13 US disclosed
US-20030195340-A1 Chromene compound MOMODA JUNJI (JP) 2003-10-16 US disclosed
US-6525194-B1 Naphtho-2,1-b-pyran derivative that develops yellow to red color TOKUYAMA CORPORATION (JP) 2003-02-25 US disclosed
US-20030028019-A1 Chromene compound MOMODA JUNJI (JP) 2003-02-06 US disclosed
EP-1122251-A1 CHROMENE COMPOUNDS TOKUYAMA CORPORATION (JP) 2001-08-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030028019-A1 Chromene compound MITF, TYR, CDYL MAPT 179/4885NPSR1 4153/4885KDM4E 513/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.