Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6757871 | 0.98 | SMN1; SMN2 (0.38) | RAB9ANPC1SMN1; SMN2KDM4EGFER | |
| SCHEMBL6762666 | 0.80 | ALDH1A1 (0.34) | RAB9ANPC1SMN1; SMN2KDM4EGFER | |
| SCHEMBL6737820 | 0.73 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2KDM4EKCNK3 | |
| SCHEMBL7990575 | 0.72 | HDAC3 (0.41) | RAB9ANPC1HTTALDH1A1LMNA | |
| SCHEMBL6876523 | 0.71 | L3MBTL1 (0.40) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4266412 | 0.68 | KCNK3 (0.61) | RAB9ANPC1SMN1; SMN2KDM4EKCNK3 | |
| SCHEMBL6179784 | 0.65 | HDAC1 (0.36) | RAB9ANPC1SMN1; SMN2KDM4EGFER | |
| SCHEMBL5847219 | 0.65 | HDAC3 (0.38) | RAB9ANPC1SMN1; SMN2GFERKCNK3 | |
| SCHEMBL5847210 | 0.65 | HDAC3 (0.38) | RAB9ANPC1SMN1; SMN2GFERKCNK3 | |
| SCHEMBL5847923 | 0.64 | LMNA (0.39) | RAB9ANPC1SMN1; SMN2GFERKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004505014-A | — | — | 2004-02-19 | — | — | JP | claimed |
| EP-1268463-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-01-02 | — | — | EP | claimed |
| WO-2001077097-A2 | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-10-18 | — | — | WO | claimed |