Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6737820 | 0.72 | RAB9A (0.45) | HDAC3HDAC1HDAC2LMNAPTPN1 | |
| SCHEMBL6760029 | 0.72 | RAB9A (0.40) | LMNARAB9ANPC1HTTALDH1A1 | |
| SCHEMBL6757871 | 0.72 | SMN1; SMN2 (0.38) | LMNARAB9ANPC1HTTALDH1A1 | |
| SCHEMBL6179784 | 0.72 | HDAC1 (0.36) | HDAC3HDAC1HDAC2PTPN1HPGD | |
| SCHEMBL6743596 | 0.70 | HDAC1 (0.50) | HDAC3HDAC1HDAC2LMNAPTPN1 | |
| SCHEMBL5847923 | 0.70 | LMNA (0.39) | HDAC3HDAC1HDAC2LMNAHPGD | |
| SCHEMBL5847219 | 0.69 | HDAC3 (0.38) | HDAC3HDAC1HDAC2LMNAPTPN1 | |
| SCHEMBL5847210 | 0.69 | HDAC3 (0.38) | HDAC3HDAC1HDAC2LMNAPTPN1 | |
| SCHEMBL7023828 | 0.68 | CTSD (0.45) | HDAC3HDAC1HDAC2ALDH1A1 | |
| SCHEMBL1196449 | 0.67 | KDM4E (0.47) | PTPN1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001087852-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL URACILS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | claimed |