Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Itaconate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | TET2 | Q6N021 | 4/20 | 0.34 |
| ▸ | TET3 | O43151 | 1/20 | 0.34 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.34 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.33 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Itaconate SCHEMBL676005 | 1.00 | ALOX15 (0.74) | ALOX15HSD17B10TSHRTP53EGLN1 | |
| Itaconate SCHEMBL20487586 | 1.00 | ALOX15 (0.74) | ALOX15HSD17B10TSHRTP53EGLN1 | |
| Itaconate SCHEMBL271206 | 1.00 | ALOX15 (0.74) | ALOX15HSD17B10TSHRTP53EGLN1 | |
| Itaconate SCHEMBL7908946 | 0.93 | ALOX15 (0.87) | ALOX15HSD17B10TSHRTP53EGLN1 | |
| Itaconate SCHEMBL17204476 | 0.93 | ALOX15 (0.65) | ALOX15HSD17B10TSHRTP53EGLN1 | |
| Itaconate SCHEMBL7908952 | 0.93 | ALOX15 (0.87) | ALOX15HSD17B10TSHRTP53EGLN1 | |
| Itaconate SCHEMBL17204479 | 0.93 | ALOX15 (0.65) | ALOX15HSD17B10TSHRTP53EGLN1 | |
| Itaconate SCHEMBL28072800 | 0.91 | ALOX15 (0.63) | ALOX15HSD17B10TSHRTP53EGLN1 | |
| Itaconate SCHEMBL7513296 | 0.89 | ALOX15 (0.71) | ALOX15HSD17B10TSHREGLN1KDM4E | |
| Itaconate SCHEMBL20487589 | 0.88 | ALOX15 (0.59) | ALOX15HSD17B10TSHRTP53EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117887384-A | Negative electrode water-based binder for improving binding performance and preparation method thereof | 常棣科技(深圳)有限公司 | 2024-04-16 | — | — | CN | claimed |
| US-20230383013-A1 | POROUS POLYMERIC CELLULOSE PREPARED VIA CELLULOSE CROSSLINKING | NANOPAREIL, LLC (GB) | 2023-11-30 | — | — | US | claimed |
| CN-116606615-A | Lithium ion battery negative electrode water-based adhesive and preparation method thereof | 常棣科技(深圳)有限公司 | 2023-08-18 | — | — | CN | claimed |
| EP-4206274-A1 | HYBRID MEMBRANE COMPRISING CROSSLINKED CELLULOSE | Nanopareil, LLC (US) | 2023-07-05 | — | — | EP | claimed |
| US-11560438-B2 | Porous polymeric cellulose prepared via cellulose crosslinking | NANOPAREIL, LLC (US) | 2023-01-24 | — | — | US | claimed |
| US-20210171665-A1 | POROUS POLYMERIC CELLULOSE PREPARED VIA CELLULOSE CROSSLINKING | NANOPAREIL, LLC | 2021-06-10 | — | — | US | claimed |
| US-10919986-B2 | Porous polymeric cellulose prepared via cellulose crosslinking | NANOPAREIL, LLC (US) | 2021-02-16 | — | — | US | claimed |
| CN-110055613-A | A kind of Paeonol terylene chips fiber and preparation method thereof | 中科纺织研究院（青岛）有限公司 | 2019-07-26 | — | — | CN | claimed |
| WO-2017189977-A1 | POROUS POLYMERIC CELLULOSE PREPARED VIA CELLULOSE CROSSLINKING | NANOPAREIL, LLC (US) | 2017-11-02 | — | — | WO | claimed |
| CN-105462287-B | A kind of extracting method of lavender dyestuff and its application in regenerated celulose fibre dyeing | 青岛百草新材料股份有限公司 | 2017-08-25 | — | — | CN | claimed |
| CN-105462287-A | Method for extracting lavender dye and application of method to regenerated cellulose fiber dyeing | QINGDAO BAICAO FIBER TECH CO LTD | 2016-04-06 | — | — | CN | claimed |
| CN-100503965-C | Method of raising light fastness of natural dye fabric | UNIV SUZHOU (CN) | 2009-06-24 | — | — | CN | claimed |
| CN-101046069-A | Method of raising light fastness of natural dye fabric | UNIV SUZHOU (CN) | 2007-10-03 | — | — | CN | claimed |
| US-5576397-A | PAINT BINDER | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-11-19 | — | — | US | claimed |
| EP-0238974-B1 | HEAT RESISTANCE-IMPROVED METAL-POLYPROPYLENE LAMINATE COMPOSITE | Chisso Corporation (JP) | 1991-12-27 | — | — | EP | claimed |
| CN-117887384-A | Negative electrode water-based binder for improving binding performance and preparation method thereof | 常棣科技(深圳)有限公司 | 2024-04-16 | — | — | CN | disclosed |
| US-11834387-B1 | Quaternary ammonium salt and preparation method and use thereof as inhibitor, and water-based drilling fluid and use thereof | YANGTZE UNIVERSITY (CN) | 2023-12-05 | — | — | US | disclosed |
| US-RE31985-E | UNSATURATED POLYESTER, SURFACTANT AND THICKENER | Dai Nippon Toryo Co, Ltd. (JP) | 1985-09-17 | — | — | US | disclosed |
| US-4520092-A | Process for preventing deposition of toner particles in an imaging apparatus | XEROX CORPORATION (US) | 1985-05-28 | — | — | US | disclosed |
| US-4296014-A | COMPRISING A POLYESTER-ACRYLIC CROSSLINKABLE GRAFT POLYMER AND A SURFACTANT OR THICKENER | DAI NIPPON TORYO CO., LTD. (JP) | 1981-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11834387-B1 | Quaternary ammonium salt and preparation method and use thereof as inhibitor, and water-based drilling fluid and use thereof | AQP1, AQP3, DDAH1 | ALOX15 3976/4885HSD17B10 702/4885TSHR 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.