Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 14/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 14/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 14/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6764518 | 0.96 | GABRG2 (0.43) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2657377 | 0.85 | CASP1 (0.38) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6761392 | 0.81 | GABRG2 (0.40) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2657958 | 0.80 | GABRG2 (0.35) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6763652 | 0.78 | GABRG2 (0.39) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2657906 | 0.72 | GABRA1 (0.45) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7000823 | 0.72 | GABRA1 (0.43) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6292520 | 0.67 | GABRG2 (0.63) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6769562 | 0.67 | GABRG2 (0.58) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7197657 | 0.64 | GABRG2 (0.54) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6730676-B2 | CENTRAL NERVOUS SYSTEM DISORDERS; COGNITION ACTIVATORS | MERCK SHARP & DOHME LTD. | 2004-05-04 | — | — | US | claimed |
| US-20030013716-A1 | Pyrazino-pyridazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-01-16 | — | — | US | claimed |
| US-6730676-B2 | CENTRAL NERVOUS SYSTEM DISORDERS; COGNITION ACTIVATORS | MERCK SHARP & DOHME LTD. | 2004-05-04 | — | — | US | disclosed |
| US-20030013716-A1 | Pyrazino-pyridazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013716-A1 | Pyrazino-pyridazine derivatives as ligands for gaba receptors | GABRA5, GABRA3, GABRA2 | GABRG2 18/4885GABRB3 7/4885GABRA3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.