SCHEMBL676519

SCHEMBL676519

C=CC(=O)OC(F)(F)C(C)F

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 8/20 0.41
ALDH1A1 P00352 5/20 0.35
TP53 P04637 3/20 0.35
HIF1A Q16665 3/20 0.35
CYP3A4 P08684 2/20 0.35
MAPK1 P28482 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HPGD P15428 1/20 0.31
HSD17B10 Q99714 1/20 0.30
THRB P10828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL64755 0.83 TSHR (0.34) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL2786089 0.80 TSHR (0.38) TSHR
SCHEMBL2777667 0.79 TSHR (0.36) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL9304290 0.79 TSHR (0.37) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL1313893 0.78
SCHEMBL3902256 0.78 TSHR (0.31) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL9301632 0.77 TSHR (0.39) TSHRALDH1A1TP53HIF1ACYP3A4
SCHEMBL2783982 0.77 TSHR (0.36) TSHR
SCHEMBL2784235 0.76 TSHR (0.35) TSHR
SCHEMBL5271257 0.76 TSHR (0.35) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12220479-B2 Suncare formulation ROHM AND HAAS COMPANY (US) 2025-02-11 US disclosed
US-12151015-B2 Color cosmetic formulation DOW GLOBAL TECHNOLOGIES LLC (US) 2024-11-26 US disclosed
US-12128125-B2 Polymer blend DOW GLOBAL TECHNOLOGIES LLC (US) 2024-10-29 US disclosed
EP-4263712-B1 METHOD OF PREPARING FILM AND COMPOSITION THEREFOR DOW SILICONES CORP (US) 2024-10-09 EP disclosed
CN-113164793-B Polymer blends for personal care formulations 陶氏环球技术有限责任公司 2024-05-17 CN disclosed
US-20240085790-A1 METHOD OF PREPARING FILM AND COMPOSITION THEREFOR DOW SILICONES CORPORATION 2024-03-14 US disclosed
EP-4263712-A1 METHOD OF PREPARING FILM AND COMPOSITION THEREFOR Dow Silicones Corporation (US) 2023-10-25 EP disclosed
CN-116529328-A Method for preparing film and composition therefor 美国陶氏有机硅公司 2023-08-01 CN disclosed
EP-3894017-B1 POLYMER BLEND FOR PERSONAL CARE FORMULATION DOW GLOBAL TECHNOLOGIES LLC (US) 2023-06-28 EP disclosed
CN-112672730-B Sun protection formulations 陶氏环球技术有限责任公司 2023-05-23 CN disclosed
US-6602949-B2 Copolymer of a vinyl monomer, a branched organosilicon compound having an ethenically unsaturated group, and a radically polymerizable surfactant; water repellent coatings with printability, storage stability DOW CORNING TORAY SILICONE CO., LTD. (JP) 2003-08-05 US disclosed
US-20030130410-A1 Coating composition for the protection of packaging and interconnecting boards SHIN-ETSU CHEMICAL CO., LTD. (JP) 2003-07-10 US disclosed
EP-1325946-A2 Coating composition for the protection of packaging and interconnecting boards SHIN-ETSU CHEMICAL CO., LTD. (JP) 2003-07-09 EP disclosed
US-6534590-B1 Vinyl monomer, carbosiloxane dendrimer, surfactant, and free radical initiator; waterproof coatings; storage stability DOW CORNING TORAY SILICONE CO., LTD. (JP) 2003-03-18 US disclosed
US-20020188069-A1 Solventless polyimide silicone resin compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 2002-12-12 US disclosed
EP-1258509-A1 Solventless polyimide silicone resin compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 2002-11-20 EP disclosed
US-20020120039-A1 Vinyl copolymer emulsion DOW TORAY CO., LTD. (JP) 2002-08-29 US disclosed
EP-1095953-A2 Silicone-grafted vinyl copolymer emulsion composition Dow Corning Toray Silicone Company, Ltd. (JP) 2001-05-02 EP disclosed
US-5336582-A Electrophotographic image formation comprising an arylamine in a charge transport layer and an encapsulated toner FUJI XEROX CO., LTD. (JP) 1994-08-09 US disclosed
US-5300388-A Toner for electrophotography and process for producing the same FUJI XEROX CO., LTD. (JP) 1994-04-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12128125-B2 Polymer blend MMAB, MMS19, C9 TSHR 2929/4885ALDH1A1 2174/4885TP53 2343/4885
US-12151015-B2 Color cosmetic formulation FDFT1, CAD, SCD5 TSHR 2892/4885ALDH1A1 395/4885TP53 1117/4885
US-12220479-B2 Suncare formulation MMS19, TLR7, CD40LG TSHR 3879/4885ALDH1A1 771/4885TP53 1495/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.