Sugi Predict

Sugi Predict / Compounds / SCHEMBL6767865

SCHEMBL6767865

SCHEMBL6767865

CSc1ccc2[nH]c(=O)[nH]c2c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.53
▸ ALDH1A1 P00352 4/20 0.53
▸ GAA P10253 3/20 0.53
▸ KDM4E B2RXH2 3/20 0.53
▸ HPGD P15428 2/20 0.53
▸ TSHR P16473 2/20 0.53
▸ HSD17B10 Q99714 2/20 0.53
▸ GRIA1 P42261 4/20 0.44
▸ CACNG8 Q8WXS5 4/20 0.44
▸ PKM P14618 2/20 0.44
▸ PDE3B Q13370 3/20 0.43
▸ PDE3A Q14432 3/20 0.43
▸ CYP1A2 P05177 1/20 0.41
▸ CYP3A4 P08684 1/20 0.41
▸ CYP2C9 P11712 1/20 0.41
▸ ALOX15 P16050 1/20 0.41
▸ NFKB1 P19838 1/20 0.41
▸ PDE4A P27815 1/20 0.41
▸ BLM P54132 1/20 0.41
▸ PMP22 Q01453 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11771146 0.88 KDM4E (0.53) MAPTALDH1A1GAAKDM4EHPGD
SCHEMBL4195289 0.81 KDM4E (0.60) MAPTALDH1A1GAAKDM4EHPGD
SCHEMBL6763628 0.79 GAA (0.44) MAPTALDH1A1GAAKDM4EHSD17B10
SCHEMBL4866368 0.77 MAPT (0.43) MAPTALDH1A1GAAKDM4EGRIA1
SCHEMBL6772885 0.76 SMN1; SMN2 (0.45) MAPTALDH1A1GAAKDM4EHPGD
SCHEMBL12322297 0.75 GAA (0.53) MAPTALDH1A1GAAKDM4EGRIA1
SCHEMBL22899950 0.71 KDM4E (0.63) MAPTALDH1A1GAAKDM4EHPGD
SCHEMBL172143 0.71 MAPT (0.54) MAPTALDH1A1GAAKDM4EGRIA1
SCHEMBL6767916 0.71 GAA (0.58) MAPTALDH1A1GAAKDM4EGRIA1
SCHEMBL21867277 0.71 NOS1 (0.62) MAPTALDH1A1GAAKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11912703-B2 6-azaindole compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2024-02-27 — — US disclosed
US-20230212158-A1 SMALL MOLECULE INHIBITORS OF GALECTIN-3 BRISTOL MYERS SQUIBB CO (US) 2023-07-06 — — US disclosed
US-20230174523-A1 BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF AMATHUS THERAPEUTICS, INC. (US) 2023-06-08 — — US disclosed
US-11420976-B2 Heterocyclic compounds as anti-viral agents ENANTA PHARMACEUTICALS, INC. (US) 2022-08-23 — — US disclosed
US-20210238188-A1 HETEROCYCLIC COMPOUNDS AS ANTI-VIRAL AGENTS ENANTA PHARMACEUTICALS, INC. 2021-08-05 — — US disclosed
US-10875839-B2 Somatostatin modulators and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2020-12-29 — — US disclosed
US-20200190053-A1 SOMATOSTATIN MODULATORS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2020-06-18 — — US disclosed
US-10351547-B2 Somatostatin modulators and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2019-07-16 — — US disclosed
US-20190002431-A1 SOMATOSTATIN MODULATORS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2019-01-03 — — US disclosed
US-9896432-B2 Somatostatin modulators and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2018-02-20 — — US disclosed
US-20180016252-A1 SOMATOSTATIN MODULATORS AND USES THEREOF Crinetics Pharmaceuticals, Inc. 2018-01-18 — — US disclosed
US-9850242-B2 Tetrahydropyrazolopyrimidine compounds EISAI R&D MANAGEMENT CO., LTD (JP) 2017-12-26 — — US disclosed
US-6699880-B1 STIMULATE MUSCARINIC ACETYLCHOLINE RECEPTORS M4, ANALGESICS BANYU PHARMACEUTICAL CO., LTD. (JP) 2004-03-02 — — US disclosed
EP-1221443-A1 SUBSTITUTED IMIDAZOLIDINONE DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 2002-07-10 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180016252-A1 SOMATOSTATIN MODULATORS AND USES THEREOF SSTR5, SSTR2, SSTR4 MAPT 3109/4885ALDH1A1 4626/4885GAA 198/4885
US-20200190053-A1 SOMATOSTATIN MODULATORS AND USES THEREOF SSTR5, SSTR2, SSTR4 MAPT 3109/4885ALDH1A1 4626/4885GAA 198/4885
US-20230212158-A1 SMALL MOLECULE INHIBITORS OF GALECTIN-3 LGALS3, LGALS1, LGALS3BP MAPT 3151/4885ALDH1A1 2713/4885GAA 173/4885
US-20210238188-A1 HETEROCYCLIC COMPOUNDS AS ANTI-VIRAL AGENTS VIP, ACE, FURIN MAPT 4216/4885ALDH1A1 1686/4885GAA 1359/4885
US-20230174523-A1 BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF TRAP1, PINK1, TP53BP1 MAPT 89/4885ALDH1A1 2569/4885GAA 1667/4885
US-11912703-B2 6-azaindole compounds TLR7, TLR9, TLR5 MAPT 4753/4885ALDH1A1 1363/4885GAA 2486/4885
US-10351547-B2 Somatostatin modulators and uses thereof SSTR5, SSTR2, SSTR4 MAPT 3109/4885ALDH1A1 4626/4885GAA 198/4885
US-20190002431-A1 SOMATOSTATIN MODULATORS AND USES THEREOF SSTR5, SSTR2, SSTR4 MAPT 3109/4885ALDH1A1 4626/4885GAA 198/4885
US-11420976-B2 Heterocyclic compounds as anti-viral agents VIP, ACE, FURIN MAPT 4216/4885ALDH1A1 1686/4885GAA 1359/4885
US-10875839-B2 Somatostatin modulators and uses thereof SSTR5, SSTR2, SSTR4 MAPT 3109/4885ALDH1A1 4626/4885GAA 198/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.