Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6767135 | 0.88 | OPRM1 (0.41) | OPRM1HTTSRCLMNAALDH1A1 | |
| SCHEMBL6770960 | 0.84 | SRC (0.43) | OPRM1HTTSRCLMNAALDH1A1 | |
| SCHEMBL6770286 | 0.83 | OPRM1 (0.56) | OPRM1HTTSRCALDH1A1PKM | |
| SCHEMBL6162529 | 0.82 | OPRM1 (0.56) | OPRM1HTTSRCLMNAALDH1A1 | |
| SCHEMBL6770454 | 0.82 | ALDH1A1 (0.48) | OPRM1HTTSRCLMNAALDH1A1 | |
| SCHEMBL6771511 | 0.80 | L3MBTL1 (0.49) | OPRM1HTTLMNAALDH1A1PKM | |
| SCHEMBL6770401 | 0.80 | OPRM1 (0.77) | OPRM1HTTLMNAALDH1A1NPSR1 | |
| SCHEMBL6770476 | 0.79 | OPRM1 (0.45) | OPRM1LMNAALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL6769828 | 0.77 | OPRM1 (0.67) | OPRM1HTTSRCLMNAALDH1A1 | |
| SCHEMBL6767074 | 0.76 | OPRM1 (0.41) | OPRM1HTTSRCLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |