Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.53 |
| ▸ | ALPL | P05186 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479730 | 0.87 | OPRM1 (0.54) | ALDH1A1LMNAOPRM1NPSR1GAA | |
| SCHEMBL6767582 | 0.86 | ALDH1A1 (0.56) | ALDH1A1LMNAOPRM1ALPLNPSR1 | |
| SCHEMBL6163724 | 0.86 | ALDH1A1 (0.65) | ALDH1A1LMNAOPRM1ALPLNPSR1 | |
| SCHEMBL6770401 | 0.82 | OPRM1 (0.77) | ALDH1A1LMNAOPRM1NPSR1HSP90AB1 | |
| SCHEMBL6767006 | 0.82 | OPRM1 (0.58) | OPRM1HSP90AB1HSP90AA1OPRD1OPRK1 | |
| SCHEMBL6770454 | 0.81 | ALDH1A1 (0.48) | ALDH1A1LMNAOPRM1ALPLNPSR1 | |
| SCHEMBL6772480 | 0.81 | ALDH1A1 (0.67) | ALDH1A1LMNAOPRM1ALPLNPSR1 | |
| SCHEMBL7533974 | 0.80 | OPRM1 (0.47) | ALDH1A1LMNAOPRM1NPSR1KMT2A | |
| SCHEMBL6767198 | 0.80 | L3MBTL1 (0.44) | ALDH1A1LMNAALPLNPSR1KMT2A | |
| SCHEMBL6770500 | 0.79 | OPRM1 (0.61) | OPRM1HSP90AB1HSP90AA1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |