Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOS | P01100 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24804536 | 0.83 | LDHA (0.55) | FOSTTRJUNNR3C1HSD17B1 | |
| SCHEMBL29954423 | 0.80 | ENPP2 (0.48) | FOSTTRJUNNR3C1HSD17B1 | |
| SCHEMBL12121962 | 0.80 | PTGS2 (0.48) | FOSTTRJUNNR3C1HSD17B1 | |
| SCHEMBL15141835 | 0.80 | ENPP2 (0.48) | FOSTTRJUNNR3C1HSD17B1 | |
| SCHEMBL806723 | 0.80 | CA2 (0.63) | FOSTTRJUNNR3C1HSD17B1 | |
| SCHEMBL25379648 | 0.79 | ENPP2 (0.47) | FOSTTRJUNNR3C1HSD17B1 | |
| SCHEMBL11571527 | 0.79 | FOS (0.80) | FOSTTRJUNNR3C1HSD17B1 | |
| SCHEMBL24803567 | 0.79 | LDHA (0.54) | ALOX15LDHATRPV1 | |
| SCHEMBL25494055 | 0.77 | GABRA1 (0.56) | FOSTTRJUNNR3C1HSD17B1 | |
| SCHEMBL6126233 | 0.77 | FOS (0.51) | FOSTTRJUNNR3C1HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673824-B1 | HYPOTENSIVE AGENTS | BRISTOL-MYERS SQUIBB CO. | 2004-01-06 | — | — | US | disclosed |
| CN-1066441-C | Phenyl sulfonamide endothelin antagonists | SQUIBB & SONS INC (US) | 2001-05-30 | — | — | CN | disclosed |
| US-6107320-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0569193-B1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-02-26 | — | — | EP | disclosed |
| US-5514696-A | Phenyl sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1996-05-07 | — | — | US | disclosed |
| CN-1084515-A | Phenyl sulfamoyl endothelium (endothelin) antagonistic | SQUIBB & SONS INC (US) | 1994-03-30 | — | — | CN | disclosed |
| EP-0569193-A1 | N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-11-10 | — | — | EP | disclosed |