Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.39 |
| ▸ | EEF2K | O00418 | 4/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.38 |
| ▸ | ITGAV | P06756 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184113 | 0.83 | NPSR1 (0.55) | EEF2KITGB3ITGAVSLC1A3SLC1A2 | |
| SCHEMBL6778678 | 0.83 | MEP1B (0.48) | ITGB3ITGAVL3MBTL1 | |
| SCHEMBL6771000 | 0.78 | ADAMTS4 (0.48) | ADAMTS4EEF2KITGB3ITGAVMMP13 | |
| SCHEMBL6772863 | 0.75 | EEF2K (0.66) | EEF2KITGB3ITGAVATMALDH1A1 | |
| SCHEMBL6771004 | 0.69 | ADAMTS4 (0.51) | ADAMTS4MMP13MMP2L3MBTL1 | |
| SCHEMBL9866942 | 0.69 | HTR2B (0.49) | ADAMTS4PKMALDH1A1 | |
| SCHEMBL6772869 | 0.68 | MMP2 (0.67) | ADAMTS4MMP13MMP2ALDH1A1L3MBTL1 | |
| SCHEMBL13444457 | 0.68 | PGR (0.44) | ADAMTS4ITGB3ITGAVMMP13MMP2 | |
| SCHEMBL4347005 | 0.67 | MMP13 (0.60) | ADAMTS4MMP13MMP2 | |
| SCHEMBL4346999 | 0.67 | MMP13 (0.60) | ADAMTS4MMP13MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833366-B1 | Dihydrostilbene alkanoic acid derivatives | PHARMACIA CORPORATION | 2004-12-21 | — | — | US | disclosed |
| US-6720315-B2 | FOR INHIBITING BONE RESORPTION, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR METASTASIS, SOLID TUMOR GROWTH, ANGIOGENESIS, MACULAR DEGENERATION AND DIABETIC RETINOPATHY RETINOPATHY | PHARMACIA CORPORATION | 2004-04-13 | — | — | US | disclosed |
| EP-1289959-A1 | DIHYDROSTILBENE ALKANOIC ACID DERIVATIVES USEFUL AS VITRONECTIN ANTAGONISTS | Pharmacia Corporation (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001096310-A1 | DIHYDROSTILBENE ALKANOIC ACID DERIVATIVES USEFUL AS VITRONECTIN ANTAGONISTS | PHARMACIA CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |