Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.35 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 4/20 | 0.36 |
| ▸ | MMP8 | P22894 | 4/20 | 0.36 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 3/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775335 | 0.88 | HCAR2 (0.45) | L3MBTL1TDP1ALDH1A1HCAR2MMP3 | |
| Maleic Acid SCHEMBL5167559 | 0.85 | L3MBTL1 (0.37) | L3MBTL1TDP1ALDH1A1HCAR2MMP3 | |
| Fumaric Acid SCHEMBL5167568 | 0.85 | L3MBTL1 (0.37) | L3MBTL1TDP1ALDH1A1HCAR2MMP3 | |
| SCHEMBL6775342 | 0.84 | HCAR2 (0.40) | L3MBTL1TDP1HCAR2MMP3MMP8 | |
| Maleic Acid SCHEMBL4564915 | 0.77 | POLB (0.43) | TDP1ALDH1A1MAPTTAAR1 | |
| Oxalic Acid SCHEMBL6765105 | 0.76 | DPP4 (0.40) | TDP1ALDH1A1 | |
| SCHEMBL13986787 | 0.76 | L3MBTL1 (0.47) | L3MBTL1TDP1MMP3MMP8MMP9 | |
| SCHEMBL3485268 | 0.75 | TSHR (0.45) | L3MBTL1TDP1MMP3MMP8MMP9 | |
| SCHEMBL3485267 | 0.75 | TSHR (0.45) | L3MBTL1TDP1MMP3MMP8MMP9 | |
| SCHEMBL2072883 | 0.75 | TSHR (0.45) | L3MBTL1TDP1MMP3MMP8MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723745-B2 | PREVENTION OR TREATMENT OF AUTOIMMUNE DISEASE IN WARM BLOODED ANIMAL | SANKYO COMPANY, LIMITED (JP) | 2004-04-20 | — | — | US | disclosed |