Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 5/20 | 0.43 |
| ▸ | THRA | P10827 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6769373 | 0.85 | MTNR1B (0.47) | MTNR1BTHRBTHRARORC | |
| SCHEMBL6765992 | 0.85 | AR (0.52) | KMT2ATHRBTHRAMEN1AR | |
| SCHEMBL6769412 | 0.74 | KDM4E (0.34) | MTNR1BTHRBTHRAKDM4ELMNA | |
| SCHEMBL6775732 | 0.74 | RORC (0.54) | MTNR1BKMT2ATHRBTHRAMEN1 | |
| SCHEMBL6775887 | 0.73 | THRB (0.36) | KMT2ATHRBMEN1KDM4ELMNA | |
| SCHEMBL7094647 | 0.70 | THRB (0.61) | THRBTHRARORC | |
| SCHEMBL7097286 | 0.70 | THRB (0.75) | THRBTHRARORC | |
| SCHEMBL8799875 | 0.70 | THRB (0.60) | THRBTHRARORC | |
| SCHEMBL6769171 | 0.70 | THRB (0.31) | KMT2ATHRBMEN1RORC | |
| SCHEMBL8798523 | 0.69 | THRB (0.54) | THRBTHRARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723717-B1 | CARDIAC-SPARING; SIDE EFFECT REDUCTION | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER | 2004-04-20 | — | — | US | disclosed |