Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 3/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | CCR2 | P41597 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6776114 | 0.85 | CCR2 (0.58) | CHKACCR2 | |
| SCHEMBL8571246 | 0.84 | CHKA (0.50) | CHKAKDM4EALDH1A1CCR2 | |
| SCHEMBL6770035 | 0.83 | KDM4E (0.57) | CACNA1GKDM4EALDH1A1DRD4CCR2 | |
| SCHEMBL11632873 | 0.82 | ALDH1A1 (0.56) | CACNA1GKDM4EALDH1A1TP53DRD4 | |
| Hydrochloric Acid SCHEMBL8479099 | 0.82 | KMT2A (0.63) | KDM4EALDH1A1MAPTHTR7 | |
| SCHEMBL3032788 | 0.81 | NPC1 (0.66) | KDM4EALDH1A1TP53HRH3 | |
| SCHEMBL13073679 | 0.80 | CACNA1G (0.53) | CACNA1GKDM4EALDH1A1DRD4GAA | |
| SCHEMBL5483874 | 0.79 | SMN1; SMN2 (0.61) | KDM4EALDH1A1TP53MAPTPOLB | |
| SCHEMBL22639905 | 0.78 | SIGMAR1 (0.61) | CACNA1GKDM4EALDH1A1DRD4DRD2 | |
| SCHEMBL2056181 | 0.78 | CHKA (0.77) | CHKAKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6686353-B1 | PREVENTING BLOOD MONOCYTES AND LYMPHOCYTES FROM INFILTRATING TISSUE | TEIJIN INTELLECTUAL PROPERTY CENTER LIMITED (JP) | 2004-02-03 | — | — | US | disclosed |
| EP-0914319-B1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LTD (JP) | 2001-11-21 | — | — | EP | disclosed |
| EP-0914319-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997044329-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1997-11-27 | — | — | WO | disclosed |