Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 7/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.42 |
| ▸ | VDR | P11473 | 1/20 | 0.42 |
| ▸ | SOX18 | P35713 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775883 | 0.89 | CTRB1 (0.41) | F10CTRB1PLA2G2ACCR2PLA2G10 | |
| SCHEMBL6782681 | 0.89 | ICMT (0.41) | F10CTRB1PLA2G2ACCR2PLA2G10 | |
| SCHEMBL6777431 | 0.88 | PARP1 (0.41) | F10CTRB1PLA2G2ACCR2PLA2G10 | |
| SCHEMBL6778086 | 0.87 | F10 (0.40) | F10CTRB1PLA2G2ACCR2PLA2G10 | |
| SCHEMBL6772036 | 0.86 | CCR2 (0.41) | F10CTRB1PLA2G2ACCR2ICMT | |
| SCHEMBL6896918 | 0.85 | SLC6A2 (0.43) | F10PLA2G2AVDRKDM4ETSHR | |
| SCHEMBL5212989 | 0.85 | PLA2G2A (0.58) | F10PLA2G2APLA2G10KDM4EALDH1A1 | |
| SCHEMBL6776370 | 0.84 | PPARG (0.44) | F10CTRB1 | |
| SCHEMBL6777891 | 0.83 | PLA2G2A (0.49) | F10PLA2G2APLA2G10KDM4EALDH1A1 | |
| SCHEMBL6775943 | 0.83 | PLA2G2A (0.49) | F10PLA2G2APLA2G10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6713645-B1 | INHIBITING SPLA2 MEDIATED RELEASE OF FATTY ACIDS FOR TREATMENT OF CONDITIONS SUCH AS SEPTIC SHOCK | ELI LILLY AND COMPANY | 2004-03-30 | — | — | US | disclosed |
| US-6177440-B1 | THERAPY FOR SEPSIS SHOCK; PHOSPHOLIPASE INHBITOR | ELI LILLY AND COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0952149-A2 | Substituted carbazoles, process for their preparation and their use as sPLA2 inhibitiors | ELI LILLY AND COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |