Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.47 |
| ▸ | GGT1 | P19440 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5605677 | 0.90 | PTGS2 (0.58) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| SCHEMBL3000316 | 0.85 | HPGD (0.54) | PTGS2HSD17B10KDM4ELMNAMAPT | |
| SCHEMBL4138781 | 0.85 | PTGS2 (0.64) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| SCHEMBL29454034 | 0.85 | PTGS2 (0.64) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| SCHEMBL4337330 | 0.84 | HSD17B10 (0.58) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| SCHEMBL4128980 | 0.81 | PTGS2 (0.56) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| SCHEMBL13588988 | 0.81 | PTGS2 (0.58) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL4120907 | 0.80 | PTGS2 (0.55) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| Ncx-4016 SCHEMBL29813476 | 0.80 | PTGS2 (0.57) | PTGS2HSD17B10KDM4ELMNACYP1A2 | |
| Ncx-4016 SCHEMBL29546681 | 0.80 | PTGS2 (0.57) | PTGS2HSD17B10KDM4ELMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120183600-A1 | NOVEL COMPOSITION FOR TREATING METABOLIC SYNDROME AND OTHER CONDITIONS | CHEN CHIEN-HUNG (US) | 2012-07-19 | — | — | US | claimed |
| US-20090075952-A1 | NITRODERVIATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS | NICOX S.A. | 2009-03-19 | — | — | US | claimed |
| EP-1339665-B1 | NITRODERIVATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS | NICOX SA (FR) | 2007-12-19 | — | — | EP | claimed |
| US-20040023933-A1 | Nitroderivatives as drugs for diseases having an inflammatory basis | NICOX S.A. (FR) | 2004-02-05 | — | — | US | claimed |
| EP-1339665-A1 | NITRODERIVATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS | Nicox S.A. (FR) | 2003-09-03 | — | — | EP | claimed |
| WO-2002030866-A1 | NITRODERIVATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS | NICOX S.A. (FR) | 2002-04-18 | — | — | WO | claimed |
| US-10450260-B2 | NO- and H2S-releasing compounds | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2019-10-22 | — | — | US | disclosed |
| EP-1933881-B1 | SOLID POLYMER DELIVERY COMPOSITIONS AND METHODS FOR USE THEREOF | MEDIVAS LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| US-20170260124-A1 | NO- AND H2S- RELEASING COMPOUNDS | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2017-09-14 | — | — | US | disclosed |
| US-9688607-B2 | No- and H2S-releasing compounds | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2017-06-27 | — | — | US | disclosed |
| EP-2744487-B1 | NO- AND H2S- RELEASING COMPOUNDS | UNIV CITY NEW YORK RES FOUND (US) | 2016-10-05 | — | — | EP | disclosed |
| US-20160206570-A1 | CARDIOPROTECTANT TO REDUCE DAMAGE FROM HEART ATTACK | ARIZIBA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY IF ARIZONA (US) | 2016-07-21 | — | — | US | disclosed |
| WO-2015034940-A1 | CARDIOPROTECTANT TO REDUCE DAMAGE FROM HEART ATTACK | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2015-03-12 | — | — | WO | disclosed |
| EP-1313794-A2 | ELASTOMERIC FUNCTIONAL BIODEGRADABLE COPOLYESTER AMIDES AND COPOLYESTER URETHANES | CORNELL RESEARCH FOUNDATION, INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| US-6512137-B1 | Esterification, reduction, halogenation, nitration | NICOX S.A. (FR) | 2003-01-28 | — | — | US | disclosed |
| WO-2003000642-A2 | DRUGS FOR CHRONIC PAINS | NICOX S.A. (FR) | 2003-01-03 | — | — | WO | disclosed |
| WO-2002030866-A1 | NITRODERIVATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS | NICOX S.A. (FR) | 2002-04-18 | — | — | WO | disclosed |
| WO-2002018477-A2 | ELASTOMERIC FUNCTIONAL BIODEGRADABLE COPOLYESTER AMIDES AND COPOLYESTER URETHANES | CORNELL RESEARCH FOUNDATION, INC. (US) | 2002-03-07 | — | — | WO | disclosed |
| EP-1147074-A1 | SYNTHESIS METHOD OF NITROXYMETHYLPHENYL ESTERS OF ASPIRIN DERIVATIVES | NICOX S.A. (FR) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044705-A1 | SYNTHESIS METHOD OF NITROXYMETHYLPHENYL ESTERS OF ASPIRIN DERIVATIVES | NICOX S.A. (FR) | 2000-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170260124-A1 | NO- AND H2S- RELEASING COMPOUNDS | NOS2, NOS3, NOS1 | PTGS2 9/4885HSD17B10 1833/4885KDM4E 2251/4885 |
| US-20090075952-A1 | NITRODERVIATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS | NR3C1, NR0B1, NOX1 | PTGS2 110/4885HSD17B10 550/4885KDM4E 3984/4885 |
| US-10450260-B2 | NO- and H2S-releasing compounds | NOS2, NOS3, NOS1 | PTGS2 9/4885HSD17B10 1833/4885KDM4E 2251/4885 |
| US-20160206570-A1 | CARDIOPROTECTANT TO REDUCE DAMAGE FROM HEART ATTACK | FABP3, TNNI3, TNNT2 | PTGS2 621/4885HSD17B10 266/4885KDM4E 4736/4885 |
| US-20040023933-A1 | Nitroderivatives as drugs for diseases having an inflammatory basis | TPMT, NOX1, CBR1 | PTGS2 64/4885HSD17B10 606/4885KDM4E 4320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.