Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 3/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6783699 | 1.00 | ALDH1A1 (0.42) | ALDH1A1XBP1NPSR1MEN1PKM | |
| SCHEMBL8225266 | 0.89 | ATP4A (0.35) | ALDH1A1MEN1HTTKMT2AMAPT | |
| SCHEMBL3325726 | 0.89 | ATP4A (0.35) | ALDH1A1MEN1HTTKMT2AMAPT | |
| SCHEMBL3325730 | 0.89 | ATP4A (0.35) | ALDH1A1MEN1HTTKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL6904332 | 0.88 | ATP4A (0.37) | ALDH1A1MEN1HTTKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL6904335 | 0.88 | ATP4A (0.37) | ALDH1A1MEN1HTTKMT2AMAPT | |
| SCHEMBL6786485 | 0.88 | PARL (0.38) | ALDH1A1MEN1KMT2AMMP2MAPT | |
| SCHEMBL6786487 | 0.88 | PARL (0.38) | ALDH1A1MEN1KMT2AMMP2MAPT | |
| Hydrochloric Acid SCHEMBL6901237 | 0.74 | LMNA (0.39) | GAA | |
| SCHEMBL6781141 | 0.74 | ALDH1A1 (0.43) | ALDH1A1MEN1HTTKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727270-B2 | PSYCHOLOGICAL, SEXUAL, EATING, AND SLEEP DISORDERS; ANXIOLYTIC, ANTIEPILEPTIC, ANTIDEPRESSANT AGENTS; OBSESSIVE COMPULSIVE DISORDER, ATTENTION DEFICIT DISORDER, MIGRAINES; COGNITION ACTIVATORS; ALZHEIMER*S AND PARKINSON*S TREATMENT | WYETH | 2004-04-27 | — | — | US | claimed |
| US-20030203895-A1 | Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2003-10-30 | — | — | US | claimed |
| WO-2003068740-A1 | PYRROLYLALKYLIDENE-HYDRAZINECARBOXIMIDAMIDE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2003-08-21 | — | — | WO | claimed |
| US-6727270-B2 | PSYCHOLOGICAL, SEXUAL, EATING, AND SLEEP DISORDERS; ANXIOLYTIC, ANTIEPILEPTIC, ANTIDEPRESSANT AGENTS; OBSESSIVE COMPULSIVE DISORDER, ATTENTION DEFICIT DISORDER, MIGRAINES; COGNITION ACTIVATORS; ALZHEIMER*S AND PARKINSON*S TREATMENT | WYETH | 2004-04-27 | — | — | US | disclosed |
| US-20030203895-A1 | Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2003-10-30 | — | — | US | disclosed |
| WO-2003068740-A1 | PYRROLYLALKYLIDENE-HYDRAZINECARBOXIMIDAMIDE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203895-A1 | Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, HTR2C | ALDH1A1 676/4885XBP1 3975/4885NPSR1 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.