SCHEMBL678404

SCHEMBL678404

CCC([C]=O)N1CCCC1

nearest known ligand 0.30

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.30
SLC6A4 P31645 1/20 0.30
SLC6A3 Q01959 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7427732 0.98 FDPS (0.32)
SCHEMBL678969 0.82 SLC6A3 (0.38) SLC6A2SLC6A4SLC6A3
SCHEMBL23668190 0.82 HTR1A (0.31) SLC6A3
SCHEMBL947586 0.80 SLC6A2 (0.35) SLC6A2SLC6A4
SCHEMBL7720713 0.80 ALDH1A1 (0.40)
SCHEMBL678787 0.79 HRH3 (0.37) SLC6A2SLC6A4SLC6A3
SCHEMBL452570 0.77 SLC6A2 (0.37) SLC6A2SLC6A4SLC6A3
SCHEMBL454026 0.77 SLC6A2 (0.37) SLC6A2SLC6A4SLC6A3
SCHEMBL455165 0.77 SLC6A2 (0.37) SLC6A2SLC6A4SLC6A3
SCHEMBL8904036 0.77 HRH3 (0.40) SLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2160192-B1 ANTIMICROBIAL MATERIALS AND COATINGS COVIDIEN LP (US) 2018-03-28 EP disclosed
US-20170096391-A1 NOVEL LACTAMS BIOSIGNAL LIMITED (AU) 2017-04-06 US disclosed
US-9586901-B2 Lactams UNILEVER PLC (GB) 2017-03-07 US disclosed
US-8586618-B2 Furanone compounds and lactam analogues thereof BIOSIGNAL LIMITED (AU) 2013-11-19 US disclosed
EP-2177226-B1 Hydroxamate compositions COVIDIEN LP (US) 2013-09-18 EP disclosed
US-20130190377-A1 Novel Lactams BIOSIGNAL LIMITED (AU) 2013-07-25 US disclosed
US-8425972-B2 Antimicrobial materials and coatings COVIDIEN LP (US) 2013-04-23 US disclosed
EP-2564859-A1 Hydroxamate compositions Covidien LP (US) 2013-03-06 EP disclosed
US-8153741-B2 Furanone copolymers TYCO HEALTHCARE GROUP LP (US) 2012-04-10 US disclosed
US-8071691-B2 Furanone endcapped polymers TYCO HEALTHCARE GROUP LP (US) 2011-12-06 US disclosed
EP-0920412-A1 ELECTROPHORESIS GELS AND CROSS-LINKING AGENTS FOR THEIR PREPARATION THE UNIVERSITY OF MELBOURNE (AU) 1999-06-09 EP disclosed
WO-1998001419-A1 ELECTROPHORESIS GELS AND CROSS-LINKING AGENTS FOR THEIR PREPARATION THE UNIVERSITY OF MELBOURNE (AU) 1998-01-15 WO disclosed
US-5610315-A Process for the preparation of 6,7-diacyl-7-deacetylforskolin derivatives NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1997-03-11 US disclosed
US-5484954-A HEATING, DEACYLATING NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1996-01-16 US disclosed
US-5302730-A Acylation with acetic acid at positions one and seven; eliminating acyl group at position seven by solvolysis NIPPON KAYAKU KK (JP) 1994-04-12 US disclosed
EP-0297496-B1 Novel process for the preparation of 6,7-Diacyl-7-deacetylforskolin derivatives NIPPON KAYAKU KK (JP) 1994-01-19 EP disclosed
EP-0222413-B1 NOVEL FORSKOLIN DERIVATIVES NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1992-02-05 EP disclosed
US-4954642-A INOTROPIC, HYPOTENSIVE NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1990-09-04 US disclosed
EP-0297496-A2 Novel process for the preparation of 6,7-Diacyl-7-deacetylforskolin derivatives NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1989-01-04 EP disclosed
EP-0222413-A2 Novel forskolin derivatives NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1987-05-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130190377-A1 Novel Lactams SULT1E1, PGLS, Q6ZSR9 SLC6A2 4441/4885SLC6A4 4658/4885SLC6A3 4395/4885
US-20170096391-A1 NOVEL LACTAMS SULT1E1, PGLS, Q6ZSR9 SLC6A2 4441/4885SLC6A4 4658/4885SLC6A3 4395/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.